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- Publisher Website: 10.1002/ange.202400838
- Scopus: eid_2-s2.0-85186230154
- PMID: 38372011
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Article: Delocalization Engineering of Heme-Mimetic Artificial Enzymes for Augmented Reactive Oxygen Catalysis
Title | Delocalization Engineering of Heme-Mimetic Artificial Enzymes for Augmented Reactive Oxygen Catalysis |
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Authors | |
Keywords | artificial enzymes biocatalysts heme-mimetic materials peroxidase-like activity reactive oxygen species |
Issue Date | 8-Apr-2024 |
Publisher | Wiley |
Citation | Angewandte Chemie International edition, 2024, v. 63, n. 15 How to Cite? |
Abstract | Developing artificial enzymes based on organic molecules or polymers for reactive oxygen species (ROS)-related catalysis has broad applicability. Herein, inspired by porphyrin-based heme mimics, we report the synthesis of polyphthalocyanine-based conjugated polymers (Fe-PPc-AE) as a new porphyrin-evolving structure to serve as efficient and versatile artificial enzymes for augmented reactive oxygen catalysis. Owing to the structural advantages, such as enhanced π-conjugation networks and π-electron delocalization, promoted electron transfer, and unique Fe−N coordination centers, Fe-PPc-AE showed more efficient ROS-production activity in terms of Vmax and turnover numbers as compared with porphyrin-based conjugated polymers (Fe-PPor-AE), which also surpassed reported state-of-the-art artificial enzymes in their activity. More interestingly, by changing the reaction medium and substrates, Fe-PPc-AE also revealed significantly improved activity and environmental adaptivity in many other ROS-related biocatalytic processes, validating the potential of Fe-PPc-AE to replace conventional (poly)porphyrin-based heme mimics for ROS-related catalysis, biosensors, or biotherapeutics. It is suggested that this study will offer essential guidance for designing artificial enzymes based on organic molecules or polymers. |
Persistent Identifier | http://hdl.handle.net/10722/347265 |
ISSN | 2023 Impact Factor: 16.1 2023 SCImago Journal Rankings: 5.300 |
DC Field | Value | Language |
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dc.contributor.author | Li, Qian | - |
dc.contributor.author | Zhao, Zhenyang | - |
dc.contributor.author | Chen, Fan | - |
dc.contributor.author | Xu, Xiaohui | - |
dc.contributor.author | Cheng, Liang | - |
dc.contributor.author | Adeli, Mohsen | - |
dc.contributor.author | Luo, Xianglin | - |
dc.contributor.author | Cheng, Chong | - |
dc.date.accessioned | 2024-09-20T00:31:03Z | - |
dc.date.available | 2024-09-20T00:31:03Z | - |
dc.date.issued | 2024-04-08 | - |
dc.identifier.citation | Angewandte Chemie International edition, 2024, v. 63, n. 15 | - |
dc.identifier.issn | 1433-7851 | - |
dc.identifier.uri | http://hdl.handle.net/10722/347265 | - |
dc.description.abstract | <p>Developing artificial enzymes based on organic molecules or polymers for reactive oxygen species (ROS)-related catalysis has broad applicability. Herein, inspired by porphyrin-based heme mimics, we report the synthesis of polyphthalocyanine-based conjugated polymers (Fe-PPc-AE) as a new porphyrin-evolving structure to serve as efficient and versatile artificial enzymes for augmented reactive oxygen catalysis. Owing to the structural advantages, such as enhanced π-conjugation networks and π-electron delocalization, promoted electron transfer, and unique Fe−N coordination centers, Fe-PPc-AE showed more efficient ROS-production activity in terms of Vmax and turnover numbers as compared with porphyrin-based conjugated polymers (Fe-PPor-AE), which also surpassed reported state-of-the-art artificial enzymes in their activity. More interestingly, by changing the reaction medium and substrates, Fe-PPc-AE also revealed significantly improved activity and environmental adaptivity in many other ROS-related biocatalytic processes, validating the potential of Fe-PPc-AE to replace conventional (poly)porphyrin-based heme mimics for ROS-related catalysis, biosensors, or biotherapeutics. It is suggested that this study will offer essential guidance for designing artificial enzymes based on organic molecules or polymers.<br></p> | - |
dc.language | eng | - |
dc.publisher | Wiley | - |
dc.relation.ispartof | Angewandte Chemie International edition | - |
dc.subject | artificial enzymes | - |
dc.subject | biocatalysts | - |
dc.subject | heme-mimetic materials | - |
dc.subject | peroxidase-like activity | - |
dc.subject | reactive oxygen species | - |
dc.title | Delocalization Engineering of Heme-Mimetic Artificial Enzymes for Augmented Reactive Oxygen Catalysis | - |
dc.type | Article | - |
dc.identifier.doi | 10.1002/ange.202400838 | - |
dc.identifier.pmid | 38372011 | - |
dc.identifier.scopus | eid_2-s2.0-85186230154 | - |
dc.identifier.volume | 63 | - |
dc.identifier.issue | 15 | - |
dc.identifier.eissn | 1521-3773 | - |
dc.identifier.issnl | 1433-7851 | - |