345. SHOULD THE ACID EXPOSURE TIME FOR DIAGNOSING ACTIONABLE GASTROESOPHAGEAL REFLUX DISEASE DIFFER IN THE ASIAN POPULATION?

Abstract

<p>Background</p><p>The Lyon Consensus 2 for actionable gastro-esophageal reflux disease (GERD) newly includes Los Angeles (LA) Grade B or above esophagitis and exceeding Acid Exposure Time (AET) of 6% on pH monitoring. Seoul Consensus 2020 provides evidence of applying different AET to the Asian population. This study aims to provide an AET for diagnosing actionable GERD in our Asian population.</p><p>Methods</p><p>Retrospective analysis of 2 cohorts of patients in 2 different Asian cities with GERD symptoms was performed. The inclusion criteria are: patients who underwent endoscopic workup, ambulatory pH monitoring and high-resolution manometry; exclusion criteria are: history of upper gastrointestinal surgery and achalasia. Sensitivity, specificity and area under the ROC curve of different AET were calculated.</p><p>Results</p><p>A total of 658 patients were included. Sensitivity and specificity for predicting LA Grade B or above oesophagitis were: AET 3.2% (91.2%, 55.6%), AET 4.0% (87.5%, 61.1%), AET 6.0% (74.3%, 73.8%). Area under curve (AUC) was highest for patients with AET of 3.55% (75.1%).</p><p>Conclusion</p><p>This study demonstrates that the highest AUC was at AET of 3.55% in our population, suggesting applying a different AET threshold in our population to diagnose actionable GERD would be more suitable.</p><p><br></p>