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Article: The detection of clinically occult nasopharyngeal carcinoma in patients following radiotherapy - An analysis of 69 patients

TitleThe detection of clinically occult nasopharyngeal carcinoma in patients following radiotherapy - An analysis of 69 patients
Authors
Nicholls, JMChua, DChiu, PMKwong, DLW
KeywordsCarcinoma
Nasopharjngeal neoplasms
Radiotherapy
Issue Date1996
PublisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=JLO
Citation
Journal of Laryngology and Otology, 1996, v. 110 n. 5, p. 496-499 How to Cite?
DOI: http://dx.doi.org/10.1017/S0022215100134097
AbstractA prospective analysis of 69 patients who had been treated for nasopharyngeal carcinoma (NPC) by external radiotherapy was carried out. Biopsies from the posterior nasopharynx were performed and analyzed by in situ hybridization using an antisense Epstein-Barr Early RNA (EBER) radio-labelled riboprobe. None of the patients had evidence of disease in the nasopharynx. One patient was found to have nasopharyngeal carcinoma detected only by in situ hybridization. In the subsequent 18-month follow-up of these clinically- and biopsynegative patients, only one patient developed relapse in the nasopharynx. In situ hybridization is a valuable tool for the detection of NPC and should be routinely available in histopathology laboratories where NPC is regularly diagnosed.
Persistent Identifierhttp://hdl.handle.net/10722/44629
ISSN
0022-2151
2023 Impact Factor: 1.1
2023 SCImago Journal Rankings: 0.550
ISI Accession Number ID
WOS:A1996UQ12600024
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorNicholls, JMen_HK
dc.contributor.authorChua, D-
dc.contributor.authorChiu, PM-
dc.contributor.authorKwong, DLW-
dc.date.accessioned2007-10-30T06:06:16Z-
dc.date.available2007-10-30T06:06:16Z-
dc.date.issued1996en_HK
dc.identifier.citationJournal of Laryngology and Otology, 1996, v. 110 n. 5, p. 496-499en_HK
dc.identifier.issn0022-2151en_HK
dc.identifier.urihttp://hdl.handle.net/10722/44629-
dc.description.abstractA prospective analysis of 69 patients who had been treated for nasopharyngeal carcinoma (NPC) by external radiotherapy was carried out. Biopsies from the posterior nasopharynx were performed and analyzed by in situ hybridization using an antisense Epstein-Barr Early RNA (EBER) radio-labelled riboprobe. None of the patients had evidence of disease in the nasopharynx. One patient was found to have nasopharyngeal carcinoma detected only by in situ hybridization. In the subsequent 18-month follow-up of these clinically- and biopsynegative patients, only one patient developed relapse in the nasopharynx. In situ hybridization is a valuable tool for the detection of NPC and should be routinely available in histopathology laboratories where NPC is regularly diagnosed.en_HK
dc.format.extent2077 bytes-
dc.format.extent2977215 bytes-
dc.format.mimetypetext/plain-
dc.format.mimetypeapplication/pdf-
dc.languageengen_HK
dc.publisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=JLOen_HK
dc.relation.ispartofJournal of Laryngology and Otologyen_HK
dc.rightsJournal of Laryngology and Otology. Copyright © Cambridge University Press.en_HK
dc.subjectCarcinomaen_HK
dc.subjectNasopharjngeal neoplasmsen_HK
dc.subjectRadiotherapyen_HK
dc.subject.meshAntisense Elements (Genetics)en_HK
dc.subject.meshHerpesvirus 4, Human - geneticsen_HK
dc.subject.meshNasopharyngeal Neoplasms - chemistry - diagnosis - radiotherapyen_HK
dc.subject.meshRNA, Viral - analysisen_HK
dc.subject.meshTumor Markers, Biological - analysis-
dc.titleThe detection of clinically occult nasopharyngeal carcinoma in patients following radiotherapy - An analysis of 69 patientsen_HK
dc.typeArticleen_HK
dc.identifier.emailNicholls, JM:nicholls@pathology.hku.hken_HK
dc.identifier.authorityNicholls, JM=rp00364en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1017/S0022215100134097-
dc.identifier.pmid8762329-
dc.identifier.scopuseid_2-s2.0-0030140571en_HK
dc.identifier.hkuros14067-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030140571&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume110en_HK
dc.identifier.issue5en_HK
dc.identifier.spage496en_HK
dc.identifier.epage499en_HK
dc.identifier.isiWOS:A1996UQ12600024-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.issnl0022-2151-

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