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- Publisher Website: 10.1378/chest.109.3.718
- Scopus: eid_2-s2.0-0011891330
- PMID: 8617082
- WOS: WOS:A1996UA04300027
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Article: p53 Mutations in non-small cell lung carcinomas in Hong Kong
Title | p53 Mutations in non-small cell lung carcinomas in Hong Kong |
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Authors | |
Keywords | Hong Kong lung carcinoma p53 |
Issue Date | 1996 |
Publisher | American College of Chest Physicians. The Journal's web site is located at http://www.chestjournal.org |
Citation | Chest, 1996, v. 109 n. 3, p. 718-726 How to Cite? |
Abstract | Lung resections from 50 Chinese patients in Hong Kong diagnosed as having non-small cell lung carcinoma were examined for the presence of mutations in the p53 gene by polymerase chain reaction single-stranded conformation polymorphism methods and for aberrant protein expression by immunostaining techniques. Eight-point mutations in the evolutionarily conserved exon 5 through 8 regions were detected. Abnormal expression of p53 detectable by immunostaining techniques was seen in 23 specimens tested. There was no statistically significant correlation between the detection of p53 aberrations and age, sex, smoking history, histologic type, and tumor stage. Aberrant p53 protein levels detectable by immunostaining were significantly associated with the clinical and nodal staging of the tumors. |
Persistent Identifier | http://hdl.handle.net/10722/49041 |
ISSN | 2023 Impact Factor: 9.5 2023 SCImago Journal Rankings: 2.123 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lung, ML | en_HK |
dc.contributor.author | Wong, MP | en_HK |
dc.contributor.author | Skaanild, MT | en_HK |
dc.contributor.author | Fok, CL | en_HK |
dc.contributor.author | Lam, WK | en_HK |
dc.contributor.author | Yew, WW | en_HK |
dc.date.accessioned | 2008-06-12T06:33:08Z | - |
dc.date.available | 2008-06-12T06:33:08Z | - |
dc.date.issued | 1996 | en_HK |
dc.identifier.citation | Chest, 1996, v. 109 n. 3, p. 718-726 | en_HK |
dc.identifier.issn | 0012-3692 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/49041 | - |
dc.description.abstract | Lung resections from 50 Chinese patients in Hong Kong diagnosed as having non-small cell lung carcinoma were examined for the presence of mutations in the p53 gene by polymerase chain reaction single-stranded conformation polymorphism methods and for aberrant protein expression by immunostaining techniques. Eight-point mutations in the evolutionarily conserved exon 5 through 8 regions were detected. Abnormal expression of p53 detectable by immunostaining techniques was seen in 23 specimens tested. There was no statistically significant correlation between the detection of p53 aberrations and age, sex, smoking history, histologic type, and tumor stage. Aberrant p53 protein levels detectable by immunostaining were significantly associated with the clinical and nodal staging of the tumors. | en_HK |
dc.format.extent | 418 bytes | - |
dc.format.mimetype | text/html | - |
dc.language | eng | en_HK |
dc.publisher | American College of Chest Physicians. The Journal's web site is located at http://www.chestjournal.org | en_HK |
dc.relation.ispartof | Chest | en_HK |
dc.subject | Hong Kong | en_HK |
dc.subject | lung carcinoma | en_HK |
dc.subject | p53 | en_HK |
dc.title | p53 Mutations in non-small cell lung carcinomas in Hong Kong | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0012-3692&volume=109&issue=3&spage=718&epage=726&date=1996&atitle=p53+mutations+in+non-small+cell+lung+carcinomas+in+Hong+Kong | en_HK |
dc.identifier.email | Lung, ML:mlilung@hku.hk | en_HK |
dc.identifier.email | Wong, MP:mwpik@hkucc.hku.hk | en_HK |
dc.identifier.authority | Lung, ML=rp00300 | en_HK |
dc.identifier.authority | Wong, MP=rp00348 | en_HK |
dc.description.nature | published_or_final_version | en_HK |
dc.identifier.doi | 10.1378/chest.109.3.718 | en_HK |
dc.identifier.pmid | 8617082 | en_HK |
dc.identifier.scopus | eid_2-s2.0-0011891330 | en_HK |
dc.identifier.hkuros | 10761 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0011891330&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 109 | en_HK |
dc.identifier.issue | 3 | en_HK |
dc.identifier.spage | 718 | en_HK |
dc.identifier.epage | 726 | en_HK |
dc.identifier.isi | WOS:A1996UA04300027 | - |
dc.publisher.place | United States | en_HK |
dc.identifier.scopusauthorid | Lung, ML=7006411788 | en_HK |
dc.identifier.scopusauthorid | Wong, MP=7403907887 | en_HK |
dc.identifier.scopusauthorid | Skaanild, MT=36927837300 | en_HK |
dc.identifier.scopusauthorid | Fok, CL=6507491075 | en_HK |
dc.identifier.scopusauthorid | Lam, WK=7203021937 | en_HK |
dc.identifier.scopusauthorid | Yew, WW=7005934631 | en_HK |
dc.identifier.issnl | 0012-3692 | - |