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Article: Variation in gene expression patterns in human gastric cancers

TitleVariation in gene expression patterns in human gastric cancers
Authors
Chen, XLeung, SYYuen, STChu, KMJi, JLi, RChan, ASYLaw, STroyanskaya, OGWong, JSo, SBotstein, DBrown, PO
Issue Date2003
PublisherAmerican Society for Cell Biology. The Journal's web site is located at http://www.molbiolcell.org/
Citation
Molecular Biology of the Cell, 2003, v. 14 n. 8, p. 3208-3215 How to Cite?
DOI: http://dx.doi.org/10.1091/mbc.E02-12-0833
AbstractGastric cancer is the world's second most common cause of cancer death. We analyzed gene expression patterns in 90 primary gastric cancers, 14 metastatic gastric cancers, and 22 nonneoplastic gastric tissues, using cDNA microarrays representing ∼30,300 genes. Gastric cancers were distinguished from nonneoplastic gastric tissues by characteristic differences in their gene expression patterns. We found a diversity of gene expression patterns in gastric cancer, reflecting variation in intrinsic properties of tumor and normal cells and variation in the cellular composition of these complex tissues. We identified several genes whose expression levels were significantly correlated with patient survival. The variations in gene expression patterns among cancers in different patients suggest differences in pathogenetic pathways and potential therapeutic strategies.
Persistent Identifierhttp://hdl.handle.net/10722/54177
ISSN
1059-1524
2023 Impact Factor: 3.1
2023 SCImago Journal Rankings: 1.566
PubMed Central ID
PMC181561
ISI Accession Number ID
WOS:000184877400012
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorChen, Xen_HK
dc.contributor.authorLeung, SYen_HK
dc.contributor.authorYuen, STen_HK
dc.contributor.authorChu, KMen_HK
dc.contributor.authorJi, Jen_HK
dc.contributor.authorLi, Ren_HK
dc.contributor.authorChan, ASYen_HK
dc.contributor.authorLaw, Sen_HK
dc.contributor.authorTroyanskaya, OGen_HK
dc.contributor.authorWong, Jen_HK
dc.contributor.authorSo, Sen_HK
dc.contributor.authorBotstein, Den_HK
dc.contributor.authorBrown, POen_HK
dc.date.accessioned2009-04-03T07:38:48Z-
dc.date.available2009-04-03T07:38:48Z-
dc.date.issued2003en_HK
dc.identifier.citationMolecular Biology of the Cell, 2003, v. 14 n. 8, p. 3208-3215en_HK
dc.identifier.issn1059-1524en_HK
dc.identifier.urihttp://hdl.handle.net/10722/54177-
dc.description.abstractGastric cancer is the world's second most common cause of cancer death. We analyzed gene expression patterns in 90 primary gastric cancers, 14 metastatic gastric cancers, and 22 nonneoplastic gastric tissues, using cDNA microarrays representing ∼30,300 genes. Gastric cancers were distinguished from nonneoplastic gastric tissues by characteristic differences in their gene expression patterns. We found a diversity of gene expression patterns in gastric cancer, reflecting variation in intrinsic properties of tumor and normal cells and variation in the cellular composition of these complex tissues. We identified several genes whose expression levels were significantly correlated with patient survival. The variations in gene expression patterns among cancers in different patients suggest differences in pathogenetic pathways and potential therapeutic strategies.en_HK
dc.languageengen_HK
dc.publisherAmerican Society for Cell Biology. The Journal's web site is located at http://www.molbiolcell.org/en_HK
dc.relation.ispartofMolecular Biology of the Cellen_HK
dc.rights© 2003 by The American Society for Cell Biology. This article is available online at https://doi.org/10.1091/mbc.e02-12-0833.en_HK
dc.subject.meshAdenocarcinoma - etiology - genetics - metabolismen_HK
dc.subject.meshGene Expression Profilingen_HK
dc.subject.meshStomach Neoplasms - etiology - genetics - metabolismen_HK
dc.subject.meshHelicobacter Infections - complicationsen_HK
dc.subject.meshOligonucleotide Array Sequence Analysisen_HK
dc.titleVariation in gene expression patterns in human gastric cancersen_HK
dc.typeArticleen_HK
dc.identifier.emailLeung, SY: suetyi@hku.hken_HK
dc.identifier.emailChu, KM: chukm@hkucc.hku.hken_HK
dc.identifier.emailLaw, S: slaw@hku.hken_HK
dc.identifier.emailWong, J: jwong@hkucc.hku.hken_HK
dc.identifier.authorityLeung, SY=rp00359en_HK
dc.identifier.authorityChu, KM=rp00435en_HK
dc.identifier.authorityLaw, S=rp00437en_HK
dc.identifier.authorityWong, J=rp00322en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1091/mbc.E02-12-0833en_HK
dc.identifier.pmid12925757-
dc.identifier.pmcidPMC181561-
dc.identifier.scopuseid_2-s2.0-12444313589en_HK
dc.identifier.hkuros78795-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-12444313589&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume14en_HK
dc.identifier.issue8en_HK
dc.identifier.spage3208en_HK
dc.identifier.epage3215en_HK
dc.identifier.isiWOS:000184877400012-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridChen, X=8978110800en_HK
dc.identifier.scopusauthoridLeung, SY=7202044886en_HK
dc.identifier.scopusauthoridYuen, ST=7103160927en_HK
dc.identifier.scopusauthoridChu, KM=7402453538en_HK
dc.identifier.scopusauthoridJi, J=7201362473en_HK
dc.identifier.scopusauthoridLi, R=7404723915en_HK
dc.identifier.scopusauthoridChan, ASY=7403168075en_HK
dc.identifier.scopusauthoridLaw, S=7202241293en_HK
dc.identifier.scopusauthoridTroyanskaya, OG=6602361421en_HK
dc.identifier.scopusauthoridWong, J=8049324500en_HK
dc.identifier.scopusauthoridSo, S=7102397384en_HK
dc.identifier.scopusauthoridBotstein, D=7102711191en_HK
dc.identifier.scopusauthoridBrown, PO=35414776900en_HK
dc.identifier.citeulike3794530-
dc.identifier.issnl1059-1524-

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