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Article: (iii) Whole-genome association studies of complex diseases

Title(iii) Whole-genome association studies of complex diseases
Authors
Sham, PCCherny, SSKao, PYPSong, YQChan, DCheung, KMC
Keywordsgenome-wide association
GWA
single nucleotide polymorphism
SNP
WGA
whole genome association
Issue Date2008
PublisherChurchill Livingstone. The Journal's web site is located at http://www.elsevier.com/locate/cuor
Citation
Current Orthopaedics, 2008, v. 22 n. 4, p. 251-258 How to Cite?
DOI: http://dx.doi.org/10.1016/j.cuor.2008.05.006
AbstractUnderstanding how the variable co-action and interaction of multiple genetic and environmental factors lead to disease occurrence may lead to novel prevention and intervention strategies. Whole-genome association (WGA) or genome-wide association (GWA) promises to determine the genetic contribution to variability in disease risk. This review is an overview of the principles of WGA and its limitations. Some essential concepts and terminology are explained. © 2008 Elsevier Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/58297
ISSN
0268-0890
ISI Accession Number ID
WOS:000260098200003
Funding AgencyGrant Number
University Grants Committee of Hong KongAoE/M-04/04
Council of Hong KongHKU 7509/03 M
HKU 7747/07 M
HKU 7759/07 M
HKU 7669/06 M
HKU 7579/05 M
National Institutes of Health (USA)EY-12562
Funding Information:

This work was supported by grants from the University Grants Committee of Hong Kong (AoE/M-04/04) and the Research Grants Council of Hong Kong (HKU 7509/03 M, HKU 7747/07 M, HKU 7759/07 M, HKU 7669/06 M and HKU 7579/05 M), and grant EY-12562 from the National Institutes of Health (USA). We also thank Deepa Natarajan for her help in editing the manuscripts.

References
References in Scopus
Grants
Developmental genomics and skeletal research

 

DC FieldValueLanguage
dc.contributor.authorSham, PCen_HK
dc.contributor.authorCherny, SSen_HK
dc.contributor.authorKao, PYPen_HK
dc.contributor.authorSong, YQen_HK
dc.contributor.authorChan, Den_HK
dc.contributor.authorCheung, KMCen_HK
dc.date.accessioned2010-05-31T03:27:39Z-
dc.date.available2010-05-31T03:27:39Z-
dc.date.issued2008en_HK
dc.identifier.citationCurrent Orthopaedics, 2008, v. 22 n. 4, p. 251-258en_HK
dc.identifier.issn0268-0890en_HK
dc.identifier.urihttp://hdl.handle.net/10722/58297-
dc.description.abstractUnderstanding how the variable co-action and interaction of multiple genetic and environmental factors lead to disease occurrence may lead to novel prevention and intervention strategies. Whole-genome association (WGA) or genome-wide association (GWA) promises to determine the genetic contribution to variability in disease risk. This review is an overview of the principles of WGA and its limitations. Some essential concepts and terminology are explained. © 2008 Elsevier Ltd. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherChurchill Livingstone. The Journal's web site is located at http://www.elsevier.com/locate/cuoren_HK
dc.relation.ispartofCurrent Orthopaedicsen_HK
dc.subjectgenome-wide associationen_HK
dc.subjectGWAen_HK
dc.subjectsingle nucleotide polymorphismen_HK
dc.subjectSNPen_HK
dc.subjectWGAen_HK
dc.subjectwhole genome associationen_HK
dc.title(iii) Whole-genome association studies of complex diseasesen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0268-0890&volume=22&spage=251&epage=258&date=2008&atitle=(iii)+Whole-genome+association+studies+of+complex+diseasesen_HK
dc.identifier.emailSham, PC: pcsham@hku.hken_HK
dc.identifier.emailCherny, SS: cherny@hku.hken_HK
dc.identifier.emailSong, YQ: songy@hku.hken_HK
dc.identifier.emailChan, D: chand@hku.hken_HK
dc.identifier.emailCheung, KMC: cheungmc@hku.hken_HK
dc.identifier.authoritySham, PC=rp00459en_HK
dc.identifier.authorityCherny, SS=rp00232en_HK
dc.identifier.authoritySong, YQ=rp00488en_HK
dc.identifier.authorityChan, D=rp00540en_HK
dc.identifier.authorityCheung, KMC=rp00387en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.cuor.2008.05.006en_HK
dc.identifier.scopuseid_2-s2.0-51249118084en_HK
dc.identifier.hkuros153462en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-51249118084&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume22en_HK
dc.identifier.issue4en_HK
dc.identifier.spage251en_HK
dc.identifier.epage258en_HK
dc.identifier.isiWOS:000260098200003-
dc.publisher.placeUnited Kingdomen_HK
dc.relation.projectDevelopmental genomics and skeletal research-
dc.identifier.scopusauthoridSham, PC=34573429300en_HK
dc.identifier.scopusauthoridCherny, SS=7004670001en_HK
dc.identifier.scopusauthoridKao, PYP=24280722500en_HK
dc.identifier.scopusauthoridSong, YQ=7404921212en_HK
dc.identifier.scopusauthoridChan, D=7402216545en_HK
dc.identifier.scopusauthoridCheung, KMC=7402406754en_HK
dc.identifier.issnl0268-0890-

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