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Article: MRI of Late Microstructural and Metabolic Alterations in Radiation-Induced Brain Injuries
Title | MRI of Late Microstructural and Metabolic Alterations in Radiation-Induced Brain Injuries |
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Authors | |
Keywords | Diffusion tensor imaging Neurotoxicity Proton magnetic resonance spectroscopy Radiotherapy Rat brain White matter |
Issue Date | 2009 |
Publisher | John Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/1053-1807/ |
Citation | Journal Of Magnetic Resonance Imaging, 2009, v. 29 n. 5, p. 1013-1020 How to Cite? |
Abstract | Purpose: To evaluate the late effects of radiation-induced damages in the rat brain by means of in vivo multipara- metric MRI. Materials and Methods: The right hemibrains of seven Sprague-Dawley rats were irradiated with a highly colli- mated 6 MV photon beam at a single dose of approximately 28 Gy. Diffusion tensor imaging (DTI), proton MR spectros- copy (1H-MRS), T2-weighted imaging, and T1-weighted im- aging were performed to the same animals 12 months after radiation treatment. Results: Compared with the contralateral side, a signifi- cantly higher percentage decrease in fractional anisotropy was observed in the ipsilateral fimbria of hippocampus (29%) than the external capsule (8%) in DTI, indicating the selective vulnerability of fimbria to radiation treatment. Furthermore, in 1H-MRS, significantly higher choline, glu- tamate, lactate, and taurine peaks by 24%, 25%, 87%, and 58%, respectively, were observed relative to creatine in the ipsilateral brain. Postmortem histology confirmed these white matter degradations as well as glial fibrillary acidic protein and glutamine synthetase immunoreactivity in- crease in the ipsilateral brain. Conclusion: The microstructural and metabolic changes in late radiation-induced brain injuries were documented in vivo. These multiparametric MRI measurements may help understand the white matter changes and neurotoxicity upon radiation treatment in a single setting. © 2009. |
Persistent Identifier | http://hdl.handle.net/10722/58645 |
ISSN | 2023 Impact Factor: 3.3 2023 SCImago Journal Rankings: 1.339 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
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dc.contributor.author | Chan, KC | en_HK |
dc.contributor.author | Khong, PI | en_HK |
dc.contributor.author | Cheung, MM | en_HK |
dc.contributor.author | Wang, S | en_HK |
dc.contributor.author | Cai, KX | en_HK |
dc.contributor.author | Wu, EX | en_HK |
dc.date.accessioned | 2010-05-31T03:34:14Z | - |
dc.date.available | 2010-05-31T03:34:14Z | - |
dc.date.issued | 2009 | en_HK |
dc.identifier.citation | Journal Of Magnetic Resonance Imaging, 2009, v. 29 n. 5, p. 1013-1020 | en_HK |
dc.identifier.issn | 1053-1807 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/58645 | - |
dc.description.abstract | Purpose: To evaluate the late effects of radiation-induced damages in the rat brain by means of in vivo multipara- metric MRI. Materials and Methods: The right hemibrains of seven Sprague-Dawley rats were irradiated with a highly colli- mated 6 MV photon beam at a single dose of approximately 28 Gy. Diffusion tensor imaging (DTI), proton MR spectros- copy (1H-MRS), T2-weighted imaging, and T1-weighted im- aging were performed to the same animals 12 months after radiation treatment. Results: Compared with the contralateral side, a signifi- cantly higher percentage decrease in fractional anisotropy was observed in the ipsilateral fimbria of hippocampus (29%) than the external capsule (8%) in DTI, indicating the selective vulnerability of fimbria to radiation treatment. Furthermore, in 1H-MRS, significantly higher choline, glu- tamate, lactate, and taurine peaks by 24%, 25%, 87%, and 58%, respectively, were observed relative to creatine in the ipsilateral brain. Postmortem histology confirmed these white matter degradations as well as glial fibrillary acidic protein and glutamine synthetase immunoreactivity in- crease in the ipsilateral brain. Conclusion: The microstructural and metabolic changes in late radiation-induced brain injuries were documented in vivo. These multiparametric MRI measurements may help understand the white matter changes and neurotoxicity upon radiation treatment in a single setting. © 2009. | en_HK |
dc.language | eng | en_HK |
dc.publisher | John Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/1053-1807/ | en_HK |
dc.relation.ispartof | Journal of Magnetic Resonance Imaging | en_HK |
dc.rights | Journal of Magnetic Resonance Imaging. Copyright © John Wiley & Sons, Inc. | en_HK |
dc.subject | Diffusion tensor imaging | en_HK |
dc.subject | Neurotoxicity | en_HK |
dc.subject | Proton magnetic resonance spectroscopy | en_HK |
dc.subject | Radiotherapy | en_HK |
dc.subject | Rat brain | en_HK |
dc.subject | White matter | en_HK |
dc.subject.mesh | Animals | en_HK |
dc.subject.mesh | Brain - metabolism - pathology - radiation effects | en_HK |
dc.subject.mesh | Brain Injuries - etiology - metabolism - pathology | en_HK |
dc.subject.mesh | Gene Expression Regulation - radiation effects | en_HK |
dc.subject.mesh | Magnetic Resonance Imaging - methods | en_HK |
dc.subject.mesh | Magnetic Resonance Spectroscopy - methods | en_HK |
dc.subject.mesh | Neurotransmitter Agents - analysis | en_HK |
dc.subject.mesh | Radiation Injuries - metabolism - pathology | en_HK |
dc.subject.mesh | Rats | en_HK |
dc.subject.mesh | Rats, Sprague-Dawley | en_HK |
dc.subject.mesh | Tissue Distribution | en_HK |
dc.title | MRI of Late Microstructural and Metabolic Alterations in Radiation-Induced Brain Injuries | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1053-1807&volume=29&spage=1013&epage=1020&date=2009&atitle=MRI+of+late+microstructural+and+metabolic+alterations+in+radiation-induced+brain+injuries | en_HK |
dc.identifier.email | Khong, PI:plkhong@hkucc.hku.hk | en_HK |
dc.identifier.email | Wu, EX:ewu1@hkucc.hku.hk | en_HK |
dc.identifier.authority | Khong, PI=rp00467 | en_HK |
dc.identifier.authority | Wu, EX=rp00193 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1002/jmri.21736 | en_HK |
dc.identifier.pmid | 19388094 | - |
dc.identifier.scopus | eid_2-s2.0-66149109627 | en_HK |
dc.identifier.hkuros | 155572 | en_HK |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-66149109627&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 29 | en_HK |
dc.identifier.issue | 5 | en_HK |
dc.identifier.spage | 1013 | en_HK |
dc.identifier.epage | 1020 | en_HK |
dc.identifier.isi | WOS:000265621200003 | - |
dc.publisher.place | United States | en_HK |
dc.identifier.scopusauthorid | Chan, KC=34968940300 | en_HK |
dc.identifier.scopusauthorid | Khong, PI=7006693233 | en_HK |
dc.identifier.scopusauthorid | Cheung, MM=24333907800 | en_HK |
dc.identifier.scopusauthorid | Wang, S=24598284300 | en_HK |
dc.identifier.scopusauthorid | Cai, KX=26321372500 | en_HK |
dc.identifier.scopusauthorid | Wu, EX=7202128034 | en_HK |
dc.identifier.issnl | 1053-1807 | - |