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Article: Systemic infection of avian influenza A virus H5N1 subtype in humans

TitleSystemic infection of avian influenza A virus H5N1 subtype in humans
Authors
Zhang, ZZhang, JHuang, KLi, KSYuen, KYGuan, YChen, HNg, WF
KeywordsAvian influenza A virus
H5N1 subtype
Human infection
Immunohistochemistry
Tissue tropism
Issue Date2009
PublisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/humpath
Citation
Human Pathology, 2009, v. 40 n. 5, p. 735-739 How to Cite?
DOI: http://dx.doi.org/10.1016/j.humpath.2008.08.015
AbstractThe viral dissemination in a patient with avian influenza A subtype H5N1 infection was retrospectively studied by the immunohistochemical localization of viral nucleoprotein antigen. The pathology was marked by diffuse alveolar damage, lymphoid depletion, and reactive hemophagocytic syndrome. Besides the lung and the upper respiratory tract, viral antigen was detected in the small and large intestinal epithelial cells, hematopoietic cells in the bone marrow, glial cells and neurons of the brain, and lymphocytes. The results confirmed that H5N1 virus disseminated to multiple organs beyond the respiratory system. However, specific pathological changes were noted in the respiratory system only, and productive viral replication confirmed by culture was noted only in the lung. More postmortem studies are needed to elucidate the pathogenesis of this highly fatal zoonotic disease. © 2009 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/59442
ISSN
0046-8177
2021 Impact Factor: 3.526
2020 SCImago Journal Rankings: 1.213
ISI Accession Number ID
WOS:000265434900017
Funding AgencyGrant Number
Research Grant CouncilHKU 74888/05M
7500/06M
Research Fund for the Control of infectious Diseases from Health, Welfare and Food Bureau, Government of Hong Kong SAR
Li Ka Shing Foundation
Providence Foundation Limited
Funding Information:

Research Grant Council (HKU 74888/05M and 7500/06M) and Research Fund for the Control of infectious Diseases from Health, Welfare and Food Bureau, Government of Hong Kong SAR, Li Ka Shing Foundation and the Providence Foundation Limited in memory of the late Dr Liu Hac Minh.

References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorZhang, Zen_HK
dc.contributor.authorZhang, Jen_HK
dc.contributor.authorHuang, Ken_HK
dc.contributor.authorLi, KSen_HK
dc.contributor.authorYuen, KYen_HK
dc.contributor.authorGuan, Yen_HK
dc.contributor.authorChen, Hen_HK
dc.contributor.authorNg, WFen_HK
dc.date.accessioned2010-05-31T03:50:10Z-
dc.date.available2010-05-31T03:50:10Z-
dc.date.issued2009en_HK
dc.identifier.citationHuman Pathology, 2009, v. 40 n. 5, p. 735-739en_HK
dc.identifier.issn0046-8177en_HK
dc.identifier.urihttp://hdl.handle.net/10722/59442-
dc.description.abstractThe viral dissemination in a patient with avian influenza A subtype H5N1 infection was retrospectively studied by the immunohistochemical localization of viral nucleoprotein antigen. The pathology was marked by diffuse alveolar damage, lymphoid depletion, and reactive hemophagocytic syndrome. Besides the lung and the upper respiratory tract, viral antigen was detected in the small and large intestinal epithelial cells, hematopoietic cells in the bone marrow, glial cells and neurons of the brain, and lymphocytes. The results confirmed that H5N1 virus disseminated to multiple organs beyond the respiratory system. However, specific pathological changes were noted in the respiratory system only, and productive viral replication confirmed by culture was noted only in the lung. More postmortem studies are needed to elucidate the pathogenesis of this highly fatal zoonotic disease. © 2009 Elsevier Inc. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/humpathen_HK
dc.relation.ispartofHuman Pathologyen_HK
dc.subjectAvian influenza A virusen_HK
dc.subjectH5N1 subtypeen_HK
dc.subjectHuman infectionen_HK
dc.subjectImmunohistochemistryen_HK
dc.subjectTissue tropismen_HK
dc.subject.meshAntigens, Viral - analysis-
dc.subject.meshAstrocytes - virology-
dc.subject.meshBlotting, Western-
dc.subject.meshInfluenza A Virus, H5N1 Subtype - isolation and purification-
dc.subject.meshInfluenza, Human - pathology - physiopathology - virology-
dc.titleSystemic infection of avian influenza A virus H5N1 subtype in humansen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0046-8177&volume=40&spage=735&epage=739&date=2009&atitle=Systemic+infection+of+avian+influenza+A+virus+H5N1+subtype+in+humanen_HK
dc.identifier.emailZhang, J: zhangajx@hkucc.hku.hken_HK
dc.identifier.emailYuen, KY: kyyuen@hkucc.hku.hken_HK
dc.identifier.emailGuan, Y: yguan@hkucc.hku.hken_HK
dc.identifier.emailChen, H: hlchen@hku.hken_HK
dc.identifier.authorityZhang, J=rp00413en_HK
dc.identifier.authorityYuen, KY=rp00366en_HK
dc.identifier.authorityGuan, Y=rp00397en_HK
dc.identifier.authorityChen, H=rp00383en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.humpath.2008.08.015en_HK
dc.identifier.pmid19121843-
dc.identifier.scopuseid_2-s2.0-64449083389en_HK
dc.identifier.hkuros163961en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-64449083389&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume40en_HK
dc.identifier.issue5en_HK
dc.identifier.spage735en_HK
dc.identifier.epage739en_HK
dc.identifier.isiWOS:000265434900017-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridZhang, Z=25930204600en_HK
dc.identifier.scopusauthoridZhang, J=12752135600en_HK
dc.identifier.scopusauthoridHuang, K=44961130600en_HK
dc.identifier.scopusauthoridLi, KS=36072420200en_HK
dc.identifier.scopusauthoridYuen, KY=36078079100en_HK
dc.identifier.scopusauthoridGuan, Y=7202924055en_HK
dc.identifier.scopusauthoridChen, H=26643315400en_HK
dc.identifier.scopusauthoridNg, WF=7401613384en_HK
dc.identifier.issnl0046-8177-

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