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Conference Paper: Hepatic ischemia/reperfusion injury promotes lung metastasis after major hepatectomy by mobilization of circulating endothelial progenitor cells

TitleHepatic ischemia/reperfusion injury promotes lung metastasis after major hepatectomy by mobilization of circulating endothelial progenitor cells
Authors
Man, KLo, CMCheng, QChen, YNg, KKCSun, BFan, ST
Issue Date2008
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jtoc/106570021
Citation
The 14th Annual Joint International Congress of the International Liver Transplantation Society (ILTS), European Liver and Intestine Transplant Association (ELITA), and European Society for Organ Transplantation (ESOT), Paris, France, 9 - 12 July 2008. In Liver Transplantation, 2008, v. 14 suppl. 1, p. S216, abstract no. 526 How to Cite?
DOI: http://dx.doi.org/10.1002/lt.21569
AbstractOBJECTIVE: We aim to explore the precise mechanism of tumor metastasis under surgical stress by investigating the impact of hepatic I/R injury on mobilization of circulating endothelial progenitor cells and regulatory T cells. MATERIALS AND METHODS: Othotopic rat liver tumor model was established in male Buffalo rats with cirrhotic liver. Major hepatectomy was performed at 3 weeks after tumor implantation in the left lobe with (I/R injury group) or without (Control group) partial hepatic ischemia/reperfusion (20/20 minutes duration on right and median lobes). The tumor growth and metastases were longitudinally monitored by Xenogen in vivo imaging system (IVIS) in live animals by detection of luminance signals from tumor cells, which stably labeled with luciferase gene. Blood samples were taken at day0, 3, 7, 17, 21 and 28 after hepatectomy for detection of IP10/CXCR4/VEGF levels, and circulating endothelial progenitor cells (CD133+ CD34+ CXCR4+ ) and Regulatory T cell (Fox3+ CD25+ CD4+ ). Circulating protein markers linking to I/R injury and …
DescriptionOral Presentation - Malignancies
This journal suppl. entitled: Abstracts: The International Liver Transplantation Society: 14th Annual International Congress, July 9–12, 2008, Paris, France
Persistent Identifierhttp://hdl.handle.net/10722/62911
ISSN
1527-6465
2021 Impact Factor: 6.112
2020 SCImago Journal Rankings: 1.814

 

DC FieldValueLanguage
dc.contributor.authorMan, Ken_HK
dc.contributor.authorLo, CMen_HK
dc.contributor.authorCheng, Qen_HK
dc.contributor.authorChen, Yen_HK
dc.contributor.authorNg, KKCen_HK
dc.contributor.authorSun, Ben_HK
dc.contributor.authorFan, STen_HK
dc.date.accessioned2010-07-13T04:11:53Z-
dc.date.available2010-07-13T04:11:53Z-
dc.date.issued2008en_HK
dc.identifier.citationThe 14th Annual Joint International Congress of the International Liver Transplantation Society (ILTS), European Liver and Intestine Transplant Association (ELITA), and European Society for Organ Transplantation (ESOT), Paris, France, 9 - 12 July 2008. In Liver Transplantation, 2008, v. 14 suppl. 1, p. S216, abstract no. 526-
dc.identifier.issn1527-6465-
dc.identifier.urihttp://hdl.handle.net/10722/62911-
dc.descriptionOral Presentation - Malignancies-
dc.descriptionThis journal suppl. entitled: Abstracts: The International Liver Transplantation Society: 14th Annual International Congress, July 9–12, 2008, Paris, France-
dc.description.abstractOBJECTIVE: We aim to explore the precise mechanism of tumor metastasis under surgical stress by investigating the impact of hepatic I/R injury on mobilization of circulating endothelial progenitor cells and regulatory T cells. MATERIALS AND METHODS: Othotopic rat liver tumor model was established in male Buffalo rats with cirrhotic liver. Major hepatectomy was performed at 3 weeks after tumor implantation in the left lobe with (I/R injury group) or without (Control group) partial hepatic ischemia/reperfusion (20/20 minutes duration on right and median lobes). The tumor growth and metastases were longitudinally monitored by Xenogen in vivo imaging system (IVIS) in live animals by detection of luminance signals from tumor cells, which stably labeled with luciferase gene. Blood samples were taken at day0, 3, 7, 17, 21 and 28 after hepatectomy for detection of IP10/CXCR4/VEGF levels, and circulating endothelial progenitor cells (CD133+ CD34+ CXCR4+ ) and Regulatory T cell (Fox3+ CD25+ CD4+ ). Circulating protein markers linking to I/R injury and …-
dc.languageengen_HK
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jtoc/106570021-
dc.relation.ispartofLiver Transplantation-
dc.rightsLiver Transplantation. Copyright © John Wiley & Sons, Inc.-
dc.titleHepatic ischemia/reperfusion injury promotes lung metastasis after major hepatectomy by mobilization of circulating endothelial progenitor cellsen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailMan, K: kwanman@hkucc.hku.hken_HK
dc.identifier.emailLo, CM: chungmlo@hkucc.hku.hken_HK
dc.identifier.emailCheng, Q: qiaocheng@hotmail.comen_HK
dc.identifier.emailChen, Y: swakchenyj@hotmail.comen_HK
dc.identifier.emailNg, KKC: kkcng95@gmail.comen_HK
dc.identifier.emailSun, B: sbs5cycl@hotmail.comen_HK
dc.identifier.emailFan, ST: stfan@hku.hken_HK
dc.identifier.authorityMan, K=rp00417en_HK
dc.identifier.authorityLo, CM=rp00412en_HK
dc.identifier.authorityFan, ST=rp00355en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1002/lt.21569-
dc.identifier.hkuros151536en_HK
dc.identifier.hkuros165541-
dc.identifier.volume14-
dc.identifier.issuesuppl. 1-
dc.identifier.spageS216, abstract no. 526-
dc.identifier.epageS217-
dc.description.otherThe 2008 Joint International Congress of the International Liver Transplantation Society (ILTS), European Liver and Intestine Transplant Association (ELITA), and European Society for Organ Transplantation (ESOT), Paris, France, 9-12 July 2008. In Liver Transplantation, 2008, v. 14 suppl. 1, p. S216, abstract no. 526-
dc.identifier.issnl1527-6465-

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