File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Expression of viral capsid protein antigen against Epstein-Barr virus in plastids of Nicotiana tabacum cv. SR1

TitleExpression of viral capsid protein antigen against Epstein-Barr virus in plastids of Nicotiana tabacum cv. SR1
Authors
Lee, MYTZhou, YLung, RWMChye, MLYip, WKZee, SYLam, E
KeywordsAntigen
Epstein-Barr virus
Plastid transformation
Tobacco
Viral capsid protein
Issue Date2006
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/71002188
Citation
Biotechnology And Bioengineering, 2006, v. 94 n. 6, p. 1129-1137 How to Cite?
DOI: http://dx.doi.org/10.1002/bit.20948
AbstractEpstein-Barr virus (EBV) infects nearly 90% of adults worldwide and is the pathogenic source of a broad spectrum of malignancies originating from lymphoid and epithelial cells. Currently, no vaccine has been developed to immunologically inactivate this virus. In infected patients, anti-EBV viral capsid antigen (VCA) immunoglobins represent some of the useful diagnostic markers for carcinoma development. To demonstrate that the EBV VCA antigen can be produced in plants, the plastid genome of tobacco (Nicotiana tabacum cv. SRI) was transformed with a VGA-expressing cassette. The EBV VCA mRNA was actively transcribed in the transplastomic plants and antigen production was detected. This study indicates that plastid transformation could be a promising strategy in EBV VCA antigen production. © 2006 Wiley Periodicals, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/68708
ISSN
0006-3592
2021 Impact Factor: 4.395
2020 SCImago Journal Rankings: 1.136
ISI Accession Number ID
WOS:000239541200013
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorLee, MYTen_HK
dc.contributor.authorZhou, Yen_HK
dc.contributor.authorLung, RWMen_HK
dc.contributor.authorChye, MLen_HK
dc.contributor.authorYip, WKen_HK
dc.contributor.authorZee, SYen_HK
dc.contributor.authorLam, Een_HK
dc.date.accessioned2010-09-06T06:06:57Z-
dc.date.available2010-09-06T06:06:57Z-
dc.date.issued2006en_HK
dc.identifier.citationBiotechnology And Bioengineering, 2006, v. 94 n. 6, p. 1129-1137en_HK
dc.identifier.issn0006-3592en_HK
dc.identifier.urihttp://hdl.handle.net/10722/68708-
dc.description.abstractEpstein-Barr virus (EBV) infects nearly 90% of adults worldwide and is the pathogenic source of a broad spectrum of malignancies originating from lymphoid and epithelial cells. Currently, no vaccine has been developed to immunologically inactivate this virus. In infected patients, anti-EBV viral capsid antigen (VCA) immunoglobins represent some of the useful diagnostic markers for carcinoma development. To demonstrate that the EBV VCA antigen can be produced in plants, the plastid genome of tobacco (Nicotiana tabacum cv. SRI) was transformed with a VGA-expressing cassette. The EBV VCA mRNA was actively transcribed in the transplastomic plants and antigen production was detected. This study indicates that plastid transformation could be a promising strategy in EBV VCA antigen production. © 2006 Wiley Periodicals, Inc.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/71002188en_HK
dc.relation.ispartofBiotechnology and Bioengineeringen_HK
dc.rightsBiotechnology and bioengineering. Copyright © John Wiley & Sons, Inc.en_HK
dc.subjectAntigenen_HK
dc.subjectEpstein-Barr virusen_HK
dc.subjectPlastid transformationen_HK
dc.subjectTobaccoen_HK
dc.subjectViral capsid proteinen_HK
dc.titleExpression of viral capsid protein antigen against Epstein-Barr virus in plastids of Nicotiana tabacum cv. SR1en_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0006-3592&volume=94&spage=1129&epage=1137&date=2006&atitle=Expression+of+viral+capsid+protein+antigen+against+Epstein-Barr+virus+in+plastids+of+Nicotiana+tabacum+cv.+SR1en_HK
dc.identifier.emailChye, ML: mlchye@hkucc.hku.hken_HK
dc.identifier.emailYip, WK: wkyip@hkucc.hku.hken_HK
dc.identifier.authorityChye, ML=rp00687en_HK
dc.identifier.authorityYip, WK=rp00833en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/bit.20948en_HK
dc.identifier.pmid16586511-
dc.identifier.scopuseid_2-s2.0-33747134398en_HK
dc.identifier.hkuros117619en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33747134398&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume94en_HK
dc.identifier.issue6en_HK
dc.identifier.spage1129en_HK
dc.identifier.epage1137en_HK
dc.identifier.isiWOS:000239541200013-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLee, MYT=12766751800en_HK
dc.identifier.scopusauthoridZhou, Y=23136063700en_HK
dc.identifier.scopusauthoridLung, RWM=22980272500en_HK
dc.identifier.scopusauthoridChye, ML=7003905460en_HK
dc.identifier.scopusauthoridYip, WK=7102784428en_HK
dc.identifier.scopusauthoridZee, SY=7004001733en_HK
dc.identifier.scopusauthoridLam, E=7102890014en_HK
dc.identifier.issnl0006-3592-

Export via OAI-PMH Interface in XML Formats

OR

Export to Other Non-XML Formats