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- Publisher Website: 10.1111/j.1478-3231.2005.01047.x
- Scopus: eid_2-s2.0-20844446169
- PMID: 15910495
- WOS: WOS:000229781700016
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Article: Macrophage migration inhibitory factor expression correlates with inflammatory changes in human chronic hepatitis B infection
Title | Macrophage migration inhibitory factor expression correlates with inflammatory changes in human chronic hepatitis B infection |
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Authors | |
Keywords | HBV Hepatic injury Inflammation MIF |
Issue Date | 2005 |
Publisher | Wiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=1478-3223&site=1 |
Citation | Liver International, 2005, v. 25 n. 3, p. 571-579 How to Cite? |
Abstract | Background: Macrophage migration inhibitory factor (MIF) has emerged to be a pivotal cytokine in immune-mediated diseases. Patients and methods: To investigate the role of MIF in chronic hepatitis B infection, we studied two groups of hepatitis B surface antigen positive patients: group 1 (immune tolerant, n = 16) and group 2 (immune clearance, n = 16). Serum level of MIF was measured by enzyme-linked immunosorbent assay and intrahepatic expression of MIF, macrophage and T-cell localisation were detected by double immunohistochemistry. Results: An increased serum MIF correlated significantly with increased serum alanine aminotransferase activity (r = 0.73, P < 0.001) and the severity of necroinflammatory injury (r = 0.642, P < 0.001). In group 2, there was marked MIF mRNA expression in all KP-1+ macrophages and CD45RO+ activated T cells and, to a lesser extent, in hepatocytes within inflammatory areas. In contrast to its mRNA expression, the cytoplasmic MIF protein level in hepatocytes, infiltrating macrophages and T cells within the inflammatory area was reduced, which probably contributed to the increased serum MIF level. Conclusions: Our data suggested that MIF played a role in sustaining cell-mediated hepatic injury during the immune-clearance phase of chronic hepatitis B infection. © Blackwell Munksgaard 2005. |
Persistent Identifier | http://hdl.handle.net/10722/83718 |
ISSN | 2023 Impact Factor: 6.0 2023 SCImago Journal Rankings: 2.087 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Zhang, HY | en_HK |
dc.contributor.author | Nanji, AA | en_HK |
dc.contributor.author | Luk, JM | en_HK |
dc.contributor.author | Huang, XR | en_HK |
dc.contributor.author | Lo, CM | en_HK |
dc.contributor.author | Chen, YX | en_HK |
dc.contributor.author | Yuen, ST | en_HK |
dc.contributor.author | Lan, HY | en_HK |
dc.contributor.author | Lau, GKK | en_HK |
dc.date.accessioned | 2010-09-06T08:44:23Z | - |
dc.date.available | 2010-09-06T08:44:23Z | - |
dc.date.issued | 2005 | en_HK |
dc.identifier.citation | Liver International, 2005, v. 25 n. 3, p. 571-579 | en_HK |
dc.identifier.issn | 1478-3223 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/83718 | - |
dc.description.abstract | Background: Macrophage migration inhibitory factor (MIF) has emerged to be a pivotal cytokine in immune-mediated diseases. Patients and methods: To investigate the role of MIF in chronic hepatitis B infection, we studied two groups of hepatitis B surface antigen positive patients: group 1 (immune tolerant, n = 16) and group 2 (immune clearance, n = 16). Serum level of MIF was measured by enzyme-linked immunosorbent assay and intrahepatic expression of MIF, macrophage and T-cell localisation were detected by double immunohistochemistry. Results: An increased serum MIF correlated significantly with increased serum alanine aminotransferase activity (r = 0.73, P < 0.001) and the severity of necroinflammatory injury (r = 0.642, P < 0.001). In group 2, there was marked MIF mRNA expression in all KP-1+ macrophages and CD45RO+ activated T cells and, to a lesser extent, in hepatocytes within inflammatory areas. In contrast to its mRNA expression, the cytoplasmic MIF protein level in hepatocytes, infiltrating macrophages and T cells within the inflammatory area was reduced, which probably contributed to the increased serum MIF level. Conclusions: Our data suggested that MIF played a role in sustaining cell-mediated hepatic injury during the immune-clearance phase of chronic hepatitis B infection. © Blackwell Munksgaard 2005. | en_HK |
dc.language | eng | en_HK |
dc.publisher | Wiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=1478-3223&site=1 | en_HK |
dc.relation.ispartof | Liver International | en_HK |
dc.subject | HBV | en_HK |
dc.subject | Hepatic injury | en_HK |
dc.subject | Inflammation | en_HK |
dc.subject | MIF | en_HK |
dc.title | Macrophage migration inhibitory factor expression correlates with inflammatory changes in human chronic hepatitis B infection | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1478-3223&volume=25&issue=3&spage=571&epage=579&date=2005&atitle=Macrophage+migration+inhibitory+factor+expression+correlates+with+inflammatory+changes+in+human+chronic+hepatitis+B+infection | en_HK |
dc.identifier.email | Luk, JM: jmluk@hkucc.hku.hk | en_HK |
dc.identifier.email | Lo, CM: chungmlo@hkucc.hku.hk | en_HK |
dc.identifier.authority | Luk, JM=rp00349 | en_HK |
dc.identifier.authority | Lo, CM=rp00412 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1111/j.1478-3231.2005.01047.x | en_HK |
dc.identifier.pmid | 15910495 | - |
dc.identifier.scopus | eid_2-s2.0-20844446169 | en_HK |
dc.identifier.hkuros | 99899 | en_HK |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-20844446169&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 25 | en_HK |
dc.identifier.issue | 3 | en_HK |
dc.identifier.spage | 571 | en_HK |
dc.identifier.epage | 579 | en_HK |
dc.identifier.isi | WOS:000229781700016 | - |
dc.publisher.place | United States | en_HK |
dc.identifier.scopusauthorid | Zhang, HY=8965962000 | en_HK |
dc.identifier.scopusauthorid | Nanji, AA=35885060300 | en_HK |
dc.identifier.scopusauthorid | Luk, JM=7006777791 | en_HK |
dc.identifier.scopusauthorid | Huang, XR=7410248090 | en_HK |
dc.identifier.scopusauthorid | Lo, CM=7401771672 | en_HK |
dc.identifier.scopusauthorid | Chen, YX=16416830300 | en_HK |
dc.identifier.scopusauthorid | Yuen, ST=7103160927 | en_HK |
dc.identifier.scopusauthorid | Lan, HY=7102710832 | en_HK |
dc.identifier.scopusauthorid | Lau, GKK=7102301257 | en_HK |
dc.identifier.citeulike | 205879 | - |
dc.identifier.issnl | 1478-3223 | - |