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Article: Prospective randomised study on radiotherapy and surgery in the treatment of oesophageal carcinoma
Title | Prospective randomised study on radiotherapy and surgery in the treatment of oesophageal carcinoma |
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Authors | |
Issue Date | 1994 |
Publisher | Elsevier (Singapore) Pte Ltd, Hong Kong Branch. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/708511/description#description |
Citation | Asian Journal Of Surgery, 1994, v. 17 n. 3, p. 223-229 How to Cite? |
Abstract | Between 1968 and 1981, a randomised prospective study was carried out on 156 patients with resectable and potentially curable middle third squamous cell carcinoma of the oesophagus. Four different management protocols were compared; surgery alone, pre-operative radiotherapy, postoperative radiotherapy and radiotherapy alone. Patients were given appropriate additional treatment for recurrent or metastatic disease. Operative mortality was significantly higher in the pre-operative radiotherapy group (30%) than in the other surgical groups (p < 0.001). The deaths were mainly due to postoperative chest infections. Of the patients initially treated with radiotherapy alone, more than one third required subsequent surgery within a year because of persistent dysphagia. In patients who failed radiotherapy treatment, the operative mortality was 54%. The radiotherapy alone group also had a significantly increased incidence of local recurrence compared with the other groups (76% vs 30% respectively, p < 0.001). Pre-operative radiotherapy had a lower incidence of metastases compared with the surgical groups, and postoperative radiotherapy had a lower incidence of local recurrence compared to surgery alone; neither, however, were statistically significant. There was no differences in the long term survival of the four groups but there were significant differences in the short and medium-term survivals. Patients treated with radiotherapy alone had the worst one- and two-year survival compared with the surgical groups (p < 0.05). Patients treated with pre-operative radiotherapy also had significantly lower six-month survival compared with the other surgical groups, chiefly because of the high operative mortality (p < 0.0025). Survival at 18 months for patients treated by postoperative radiotherapy was also worse than the surgery alone group (p < 0.05). It was concluded that surgery alone was the best primary treatment for resectable oesophageal cancer. |
Persistent Identifier | http://hdl.handle.net/10722/83864 |
ISSN | 2023 Impact Factor: 3.5 2023 SCImago Journal Rankings: 0.538 |
DC Field | Value | Language |
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dc.contributor.author | Fok, M | en_HK |
dc.contributor.author | McShane, J | en_HK |
dc.contributor.author | Law, SYK | en_HK |
dc.contributor.author | Wong, J | en_HK |
dc.date.accessioned | 2010-09-06T08:46:08Z | - |
dc.date.available | 2010-09-06T08:46:08Z | - |
dc.date.issued | 1994 | en_HK |
dc.identifier.citation | Asian Journal Of Surgery, 1994, v. 17 n. 3, p. 223-229 | en_HK |
dc.identifier.issn | 1015-9584 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/83864 | - |
dc.description.abstract | Between 1968 and 1981, a randomised prospective study was carried out on 156 patients with resectable and potentially curable middle third squamous cell carcinoma of the oesophagus. Four different management protocols were compared; surgery alone, pre-operative radiotherapy, postoperative radiotherapy and radiotherapy alone. Patients were given appropriate additional treatment for recurrent or metastatic disease. Operative mortality was significantly higher in the pre-operative radiotherapy group (30%) than in the other surgical groups (p < 0.001). The deaths were mainly due to postoperative chest infections. Of the patients initially treated with radiotherapy alone, more than one third required subsequent surgery within a year because of persistent dysphagia. In patients who failed radiotherapy treatment, the operative mortality was 54%. The radiotherapy alone group also had a significantly increased incidence of local recurrence compared with the other groups (76% vs 30% respectively, p < 0.001). Pre-operative radiotherapy had a lower incidence of metastases compared with the surgical groups, and postoperative radiotherapy had a lower incidence of local recurrence compared to surgery alone; neither, however, were statistically significant. There was no differences in the long term survival of the four groups but there were significant differences in the short and medium-term survivals. Patients treated with radiotherapy alone had the worst one- and two-year survival compared with the surgical groups (p < 0.05). Patients treated with pre-operative radiotherapy also had significantly lower six-month survival compared with the other surgical groups, chiefly because of the high operative mortality (p < 0.0025). Survival at 18 months for patients treated by postoperative radiotherapy was also worse than the surgery alone group (p < 0.05). It was concluded that surgery alone was the best primary treatment for resectable oesophageal cancer. | en_HK |
dc.language | eng | en_HK |
dc.publisher | Elsevier (Singapore) Pte Ltd, Hong Kong Branch. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/708511/description#description | en_HK |
dc.relation.ispartof | Asian Journal of Surgery | en_HK |
dc.title | Prospective randomised study on radiotherapy and surgery in the treatment of oesophageal carcinoma | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1015-9584&volume=17&spage=223&epage=229&date=1994&atitle=Prospective+randomised+study+on+radiotherapy+and+surgery+in+the+treatment+of+oesophageal+carcinoma | en_HK |
dc.identifier.email | Law, SYK: slaw@hku.hk | en_HK |
dc.identifier.email | Wong, J: jwong@hkucc.hku.hk | en_HK |
dc.identifier.authority | Law, SYK=rp00437 | en_HK |
dc.identifier.authority | Wong, J=rp00322 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.scopus | eid_2-s2.0-0028135192 | en_HK |
dc.identifier.hkuros | 7162 | en_HK |
dc.identifier.volume | 17 | en_HK |
dc.identifier.issue | 3 | en_HK |
dc.identifier.spage | 223 | en_HK |
dc.identifier.epage | 229 | en_HK |
dc.publisher.place | Hong Kong | en_HK |
dc.identifier.scopusauthorid | Fok, M=7005879262 | en_HK |
dc.identifier.scopusauthorid | McShane, J=23393225000 | en_HK |
dc.identifier.scopusauthorid | Law, SYK=7202241293 | en_HK |
dc.identifier.scopusauthorid | Wong, J=8049324500 | en_HK |
dc.identifier.issnl | 1015-9584 | - |