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- Publisher Website: 10.1002/gcc.10048
- Scopus: eid_2-s2.0-0036204112
- PMID: 11921287
- WOS: WOS:000174537700012
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Article: Mapping of nasopharyngeal carcinoma tumor-suppressive activity to a 1.8-Megabase region of chromosome band 11q13
Title | Mapping of nasopharyngeal carcinoma tumor-suppressive activity to a 1.8-Megabase region of chromosome band 11q13 |
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Authors | |
Issue Date | 2002 |
Publisher | John Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/38250 |
Citation | Genes Chromosomes And Cancer, 2002, v. 34 n. 1, p. 97-103 How to Cite? |
Abstract | Nasopharyngeal carcinoma (NPC) is a malignancy that is particularly prevalent among populations from Southern China and Southeast Asian countries. Evidence for a genetic contribution to the disease has been documented, although the genetic basis for NPC development is not yet fully understood. Previous functional evidence of tumor-suppressive activity on chromosome band 11q13 in NPC was obtained using a microcell-mediated chromosome-transfer approach with HONE1 NPC cells. In the present study, this region was subjected to a detailed investigation of microcell hybrids and their tumor segregants using microsatellite analysis to narrow down the region of tumor-suppressive activity. Fluorescence in situ hybridization was also performed with BAC and cosmid probes to confirm the microsatellite data. The critical region responsible for tumor suppression was narrowed down to a 1.8-Mb interval, which does not tolerate an additional normal allele by chromosome transfer. One or two alleles from either endogenous or exogenous chromosomes at 11q13 were consistently eliminated during tumor growth. Results of this study suggest that a candidate tumor-suppressor gene, not the MEN1 gene, maps between D11S4907 and GSTP1 in NPC. © 2002 Wiley-Liss, Inc. |
Persistent Identifier | http://hdl.handle.net/10722/84004 |
ISSN | 2023 Impact Factor: 3.1 2023 SCImago Journal Rankings: 1.110 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
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dc.contributor.author | Cheng, Y | en_HK |
dc.contributor.author | Chakrabarti, R | en_HK |
dc.contributor.author | GarciaBarcelo, M | en_HK |
dc.contributor.author | Ha, TJ | en_HK |
dc.contributor.author | Srivatsan, ES | en_HK |
dc.contributor.author | Stanbridge, EJ | en_HK |
dc.contributor.author | Lung, ML | en_HK |
dc.date.accessioned | 2010-09-06T08:47:47Z | - |
dc.date.available | 2010-09-06T08:47:47Z | - |
dc.date.issued | 2002 | en_HK |
dc.identifier.citation | Genes Chromosomes And Cancer, 2002, v. 34 n. 1, p. 97-103 | en_HK |
dc.identifier.issn | 1045-2257 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/84004 | - |
dc.description.abstract | Nasopharyngeal carcinoma (NPC) is a malignancy that is particularly prevalent among populations from Southern China and Southeast Asian countries. Evidence for a genetic contribution to the disease has been documented, although the genetic basis for NPC development is not yet fully understood. Previous functional evidence of tumor-suppressive activity on chromosome band 11q13 in NPC was obtained using a microcell-mediated chromosome-transfer approach with HONE1 NPC cells. In the present study, this region was subjected to a detailed investigation of microcell hybrids and their tumor segregants using microsatellite analysis to narrow down the region of tumor-suppressive activity. Fluorescence in situ hybridization was also performed with BAC and cosmid probes to confirm the microsatellite data. The critical region responsible for tumor suppression was narrowed down to a 1.8-Mb interval, which does not tolerate an additional normal allele by chromosome transfer. One or two alleles from either endogenous or exogenous chromosomes at 11q13 were consistently eliminated during tumor growth. Results of this study suggest that a candidate tumor-suppressor gene, not the MEN1 gene, maps between D11S4907 and GSTP1 in NPC. © 2002 Wiley-Liss, Inc. | en_HK |
dc.language | eng | en_HK |
dc.publisher | John Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/38250 | en_HK |
dc.relation.ispartof | Genes Chromosomes and Cancer | en_HK |
dc.rights | Genes, Chromosomes & Cancer. Copyright © John Wiley & Sons, Inc. | en_HK |
dc.subject.mesh | Chromosome Mapping - methods | - |
dc.subject.mesh | Chromosomes, Human, Pair 11 - genetics | - |
dc.subject.mesh | Genes, Tumor Suppressor | - |
dc.subject.mesh | Genetic Markers - genetics | - |
dc.subject.mesh | Nasopharyngeal Neoplasms - genetics | - |
dc.title | Mapping of nasopharyngeal carcinoma tumor-suppressive activity to a 1.8-Megabase region of chromosome band 11q13 | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1045-2257&volume=34&issue=1&spage=97&epage=103&date=2002&atitle=Mapping+of+nasopharyngeal+carcinoma+tumor-suppressive+activity+to+a+1.8-megabase+region+of+chromosome+band+11q13 | en_HK |
dc.identifier.email | Cheng, Y: yuecheng@hku.hk | en_HK |
dc.identifier.email | GarciaBarcelo, M: mmgarcia@hkucc.hku.hk | en_HK |
dc.identifier.email | Lung, ML: mlilung@hku.hk | en_HK |
dc.identifier.authority | Cheng, Y=rp01320 | en_HK |
dc.identifier.authority | GarciaBarcelo, M=rp00445 | en_HK |
dc.identifier.authority | Lung, ML=rp00300 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1002/gcc.10048 | en_HK |
dc.identifier.pmid | 11921287 | en_HK |
dc.identifier.scopus | eid_2-s2.0-0036204112 | en_HK |
dc.identifier.hkuros | 79176 | en_HK |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0036204112&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 34 | en_HK |
dc.identifier.issue | 1 | en_HK |
dc.identifier.spage | 97 | en_HK |
dc.identifier.epage | 103 | en_HK |
dc.identifier.isi | WOS:000174537700012 | - |
dc.publisher.place | United States | en_HK |
dc.identifier.scopusauthorid | Cheng, Y=36131038300 | en_HK |
dc.identifier.scopusauthorid | Chakrabarti, R=7102638262 | en_HK |
dc.identifier.scopusauthorid | GarciaBarcelo, M=6701767303 | en_HK |
dc.identifier.scopusauthorid | Ha, TJ=23103098800 | en_HK |
dc.identifier.scopusauthorid | Srivatsan, ES=7004357040 | en_HK |
dc.identifier.scopusauthorid | Stanbridge, EJ=7103249410 | en_HK |
dc.identifier.scopusauthorid | Lung, ML=7006411788 | en_HK |
dc.identifier.issnl | 1045-2257 | - |