File Download
There are no files associated with this item.
Supplementary
Conference Paper: Manganese-enhanced MRI of severe hypoxic-ischemic injuries in neonatal rat model
| Title | Manganese-enhanced MRI of severe hypoxic-ischemic injuries in neonatal rat model |
|---|---|
| Authors | |
| Issue Date | 2007 |
| Publisher | International Society for Magnetic Resonance in Medicine. |
| Citation | The 2007 ISMRM-ESMRMB Joint Annual Meeting, Berlin, Germany, 19-25 May 2007. In Conference Proceedings, 2007, p. 72, abstract no. 313 How to Cite? |
| Abstract | This study aims to investigate the spatial-temporal MRI changes with and without systemic MnCl2 injection in neonatal rats with severe hypoxic-ischemic
(H-I) injury. Manganese-enhanced MRI (MEMRI) by intraperitoneal injection enhanced the detection of damages in cortical, hippocampus and basal ganglia
regions during the middle and later phase of neonatal H-I injury. However, in acute phase, no Mn enhancement was observed in edema area despite that
blood-brain-barrier is disrupted. Histopathological examinations revealed that T1-weighted Mn enhancement by exogenous Mn was associated with
increased Mn-superoxide dismutase (MnSOD) production, and hypointensity in T2-weighted MRI was associated with iron and Mn accumulation. |
| Persistent Identifier | http://hdl.handle.net/10722/98758 |
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Yang, J | en_HK |
| dc.contributor.author | Ma, D | en_HK |
| dc.contributor.author | Wang, Y | en_HK |
| dc.contributor.author | Khong, PL | en_HK |
| dc.contributor.author | Wu, EX | en_HK |
| dc.date.accessioned | 2010-09-25T18:01:06Z | - |
| dc.date.available | 2010-09-25T18:01:06Z | - |
| dc.date.issued | 2007 | en_HK |
| dc.identifier.citation | The 2007 ISMRM-ESMRMB Joint Annual Meeting, Berlin, Germany, 19-25 May 2007. In Conference Proceedings, 2007, p. 72, abstract no. 313 | - |
| dc.identifier.uri | http://hdl.handle.net/10722/98758 | - |
| dc.description.abstract | This study aims to investigate the spatial-temporal MRI changes with and without systemic MnCl2 injection in neonatal rats with severe hypoxic-ischemic (H-I) injury. Manganese-enhanced MRI (MEMRI) by intraperitoneal injection enhanced the detection of damages in cortical, hippocampus and basal ganglia regions during the middle and later phase of neonatal H-I injury. However, in acute phase, no Mn enhancement was observed in edema area despite that blood-brain-barrier is disrupted. Histopathological examinations revealed that T1-weighted Mn enhancement by exogenous Mn was associated with increased Mn-superoxide dismutase (MnSOD) production, and hypointensity in T2-weighted MRI was associated with iron and Mn accumulation. | - |
| dc.language | eng | en_HK |
| dc.publisher | International Society for Magnetic Resonance in Medicine. | - |
| dc.relation.ispartof | ISMRM-ESMRMB 2007 Joint Annual Meeting Proceedings | en_HK |
| dc.title | Manganese-enhanced MRI of severe hypoxic-ischemic injuries in neonatal rat model | en_HK |
| dc.type | Conference_Paper | en_HK |
| dc.identifier.email | Khong, PL: plkhong@hkucc.hku.hk | en_HK |
| dc.identifier.email | Wu, EX: ewu@eee.hku.hk | en_HK |
| dc.identifier.authority | Khong, PL=rp00467 | en_HK |
| dc.identifier.authority | Wu, EX=rp00193 | en_HK |
| dc.identifier.hkuros | 128816 | en_HK |
| dc.identifier.hkuros | 141501 | - |
| dc.identifier.spage | 72, abstract no. 313 | - |
| dc.identifier.epage | 72, abstract no. 313 | - |