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Conference Paper: Magnetic resonance imaging of delayed administration of manganese after transient focal cerebral ischemia

TitleMagnetic resonance imaging of delayed administration of manganese after transient focal cerebral ischemia
Authors
Chan, KCHung, VKCheung, MMCai, KXCheung, DKChui, CTChan, PMZhao, XGChung, SKWu, EX
Issue Date2008
PublisherInternational Society of Magnetic Resonance in Medicine
Citation
International Society of Magnetic Resonance in Medicine (ISMRM) 16th Scientific Meeting and Exhibition, Toronto, Canada, 3-9 May 2008, p. 3289 How to Cite?
AbstractThis study aims to employ in vivo magnetic resonance imaging to understand longitudinally the effect of systemic MnCl2 administration on delayed secondary changes after transient middle cerebral artery occlusion (MCAO). Results showed a significant increase in T1 signal intensities in the perilesional rim compared to the ischemic core in dorsolateral striatum 24 hours after Mn2+ injection, whereas colocalization was found between manganese-enhanced MRI pattern and immunostaining for GFAP, MnSOD and GS, likely due to their Mn-dependent upregulation against oxidative stress and glutamate excitotoxicity. Total ipsilateral infarcted volumes in the posterior parts of the brain had also significantly reduced after Mn2+ injection, illustrating the potential neuroprotective effects of manganese upon delayed postischemic administration.
Persistent Identifierhttp://hdl.handle.net/10722/98843

 

DC FieldValueLanguage
dc.contributor.authorChan, KCen_HK
dc.contributor.authorHung, VKen_HK
dc.contributor.authorCheung, MMen_HK
dc.contributor.authorCai, KXen_HK
dc.contributor.authorCheung, DKen_HK
dc.contributor.authorChui, CTen_HK
dc.contributor.authorChan, PMen_HK
dc.contributor.authorZhao, XGen_HK
dc.contributor.authorChung, SKen_HK
dc.contributor.authorWu, EXen_HK
dc.date.accessioned2010-09-25T18:04:34Z-
dc.date.available2010-09-25T18:04:34Z-
dc.date.issued2008en_HK
dc.identifier.citationInternational Society of Magnetic Resonance in Medicine (ISMRM) 16th Scientific Meeting and Exhibition, Toronto, Canada, 3-9 May 2008, p. 3289en_HK
dc.identifier.urihttp://hdl.handle.net/10722/98843-
dc.description.abstractThis study aims to employ in vivo magnetic resonance imaging to understand longitudinally the effect of systemic MnCl2 administration on delayed secondary changes after transient middle cerebral artery occlusion (MCAO). Results showed a significant increase in T1 signal intensities in the perilesional rim compared to the ischemic core in dorsolateral striatum 24 hours after Mn2+ injection, whereas colocalization was found between manganese-enhanced MRI pattern and immunostaining for GFAP, MnSOD and GS, likely due to their Mn-dependent upregulation against oxidative stress and glutamate excitotoxicity. Total ipsilateral infarcted volumes in the posterior parts of the brain had also significantly reduced after Mn2+ injection, illustrating the potential neuroprotective effects of manganese upon delayed postischemic administration.-
dc.languageengen_HK
dc.publisherInternational Society of Magnetic Resonance in Medicine-
dc.relation.ispartof2008 Proceedings of International Society of Magnetic Resonance in Medicineen_HK
dc.titleMagnetic resonance imaging of delayed administration of manganese after transient focal cerebral ischemiaen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailWu, EX: ewu@eee.hku.hken_HK
dc.identifier.authorityWu, EX=rp00193en_HK
dc.identifier.hkuros141573en_HK
dc.identifier.spage3289en_HK

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