Dataset
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Title of Dataset
GSE24533: Expression data of influenza A-infected human type I-like alveolar epithelial cells
Data from: Systems-level comparison of host responses induced by pandemic and seasonal influenza A H1N1 viruses in primary human type I-like alveolar epithelial cells in vitro
Author of Dataset
Contact
Date of Dataset Creation
2010-10-05
Description
Pandemic influenza H1N1 (pdmH1N1) virus causes mild disease in humans but occasionally leads to severe complications and even death, especially in those who are pregnant or have underlying disease. Cytokine responses induced by pdmH1N1 viruses in vitro are comparable to other seasonal influenza viruses, suggesting the cytokine dysregulation as seen in H5N1 infection is not a feature of the pdmH1N1 virus. However, a comprehensive gene expression profile of pdmH1N1 in relevant primary human cells in vitro has not been reported. Type I alveolar epithelial cells are a key target cell in pdmH1N1 pneumonia. We carried out a comprehensive gene expression profiling using the Affymetrix microarray platform to compare the transcriptomes of primary human alveolar type I-like alveolar epithelial cells infected with pdmH1N1 or seasonal H1N1 virus.
Citation
Lee, SMY, Chan, RW, Gardy, JL, Lo, CK, Sihoe, AD, Kang, SS, Cheung, TK, Guan, Y, Chan, MC, Hancock, RE, Peiris, JM. (2010). GSE24533: Expression data of influenza A-infected human type I-like alveolar epithelial cells. [Data File]. https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE24533
Subject (RGC Codes)
M2 — Medicine, Dentistry & Health — 醫學, 牙科學及保健
- 1211 — Epidemiology — 流行病學
Subject (ANZSRC)
11 — MEDICAL AND HEALTH SCIENCES — 醫學與衛生科學
- 1108 — MEDICAL MICROBIOLOGY — 醫學微生物學
- 110802 — Medical Infection Agents (incl. Prions) — 醫學致病因子
Keyword
Homo sapiens
Affiliations
- Department of Microbiology, The University of Hong Kong, Hong Kong SAR, PR China
- Department of Microbiology, The University of Hong Kong, Hong Kong SAR, PR China ; Department of Pathology, The University of Hong Kong, Hong Kong SAR, PR China
- British Columbia Centre for Disease Control, Vancouver, British Columbia, Canada
- Department of Cardiothoracic Surgery, Queen Elizabeth Hospital, Kowloon, Hong Kong SAR, PR China
- Department of Cardiothoracic Surgery, Queen Mary Hospital, Pokfulam, Hong Kong SAR, PR China
- Centre for Microbial Diseases and Immunity Research, University of British Columbia, Vancouver, British Columbia, Canada
- Department of Microbiology, The University of Hong Kong, Hong Kong SAR, PR China ; The University of Hong Kong-Pasteur Research Centre, Hong Kong SAR, PR China