Dr Chan, Michael Chi Wai 陳志偉
- Prophylactic and therapeutic drug trial against influenza virus infection
- Transepithelial migration, alveolar fluid clearance and protein permeability of alveolar epithelium during influenza virus infection
- In vitro and ex vivo culture of human upper, conducting and lower respiratory epithelium
- Cell biology, polarization and differentiation of human respiratory epithelial cells
- Tissue tropism of human and avian influenza virus in human
- Sialic acid receptors in human respiratory tract
- Virus and host interaction: viral replication competence, innate immune responses and apoptosis
- Lung injury, repair and regeneration of alveolar epithelium
Dr Michael Chan received his PhD degree in Medical Science from the Chinese University of Hong Kong, followed by the post-doctoral fellowships in influenza research at the University of Hong Kong in 2004.
Dr Chan main research interests are the virus-host interaction and pathogenesis of influenza virus and SARS and MERS coronavirus using ex vivo human respiratory explant cultures and in vitro well-differentiated human respiratory epithelial cells. Major focuses of his current work are: (1) Risk assessment of influenza virus and coronavirus using ex vivo explants and in vitro respiratory epithelial cells model. (2) Mechanism of lung injury upon severe influenza virus and coronavirus infection (3) Role of human distal airway stem cells in respiratory epithelium regeneration upon influenza H5N1 virus, SARS and MERS-CoV infection. (4) Role of mesenchymal stromal cells in reverse influenza H5N1 associated acute lung injury (5) Novel therapeutic agents for severe influenza virus and coronavirus infection.
Dr Chan is ranked by Essential Science Indicator (ISI) as a “top 1% most-cited international scientist” in the world. He has published over 60 manuscripts; many of them are in high impact journals including Lancet Respiratory Medicine, Nature Medicine, PNAS, European Respiratory Journal, PLoS Pathogens, Journal of Virology, Respiratory Research and Gastroenterology which are among the top peer-reviewed scientific journals.
Dr Chan has received research funding as a Principal Investigator from various local and oversea research organizations, including NIAID-CEIRS (USA), Theme-based Research Scheme, Area of Excellence Scheme and GRF (RGC, Hong Kong), ITF grant (ITC, Hong Kong), HMRF (Hong Kong). Since 2005, Dr Chan has secured research funding with a total amount of over HK$ 38 million. In addition, he has trained and currently training 12 postgraduate research students.
Dr Chan has worked as the visiting scientists in the Department of Anesthesia and Medicine, Centre for Regenerative Studies, Brigham and Women's Hospital, Harvard Medical School and the Cardiovascular Research Institute, University of California, San Francisco. Furthermore, he is an Academic Editor of PLoS ONE, Associate Editor of Frontiers in Microbiology and the editorial broad member of the Open Journal of Respiratory diseases, International Journal of Clinical and Experimental Pathology and Medicine. He reviews manuscripts regularly for various international peer-review top tier journals.
|Awardees||Award Date||Honours / Awards / Prizes||Category|
|2008-07-01||2008 Research Output Prize/Faculty Outstanding Research Output Award: The University of Hong Kong||Research Achievement|
|2006-07-01||ASV Postdoctoral Fellow Travel Award: American Society for Virology||Research Achievement|
|2004-02-01||Professor John Vallance-Owen Award for Young Basic Scientists: The Chinese University of Hong Kong||Research Achievement|
|2007-06-01||Promising Investigator Scholarship: Options for the Control of Influenza VI||Research Achievement|
|Term Period||Position||Professional Societies|
|01/2010-12/2013||Full member||American Society for Microbiology|
|01/2009/-12/2013||Full member||American Society for Virology|
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