Professor Dora Kwong 鄺麗雲
|1988||The University of Hong Kong||MBBS|
|2006||The University of Hong Kong||MD|
|1993||The Royal College of Radiologists||FRCR|
|1996||Hong Kong Academy of Medicine||FHKCR|
|1996||The Hong Kong Academy of Medicine||FHKAM|
|1997||The University of Wales Swansea||Postgraduate Diploma in Health Care Management|
Prof. Dora Kwong is currently Clinical Professor and Head of Department of Clinical Oncology. Prof. Kwong graduated from the University of Hong Kong in 1988 and became Fellow of the Royal College of Radiologists in 1993 and Fellow of Hong Kong College of Radiologists and Fellow of Hong Kong Academy of Medicine in 1996. She obtained her Doctor of Medicine degree from the University of Hong Kong in 2006.
Her research interests include head and neck cancer with an emphasis on nasopharyngeal carcinoma (NPC), upper GI cancers including CA esophagus and CA stomach and paediatric cancers. She is involved in multiciplinary management employing both medical treatment and radiotherapy. She is also interested in basic research in carcinogenesis and translational research in identifying prognostic and predictor biomarkers.
For nasopharyngeal carcinoma, her randomised factorial study on concurrent and adjuvant chemotherapy in NPC is one of the studies included in metaanalysis of NPC which confirmed the importance of concurrent chemoradiotherapy in improving survival of NPC. She pioneered the use of intensity modulation radiotherapy (IMRT) in treatment of NPC in Hong Kong showing the advantage of IMRT in preserving salivary function, improving quality of life in early NPC and allowing dose escalation and improved local control in locally advanced NPC. Both concurrent chemoradiotherapy and IMRT have now been adopted as standard of care in treatment of NPC. Currently we are investigating the role of functional imaging like PET scan in predicting for early disease response and incorporating biological target volume in IMRT in order to adapt radiotherapy to individual disease response during treatment. In laboratory research, we studied the function of a number of novel tumor suppressor genes and found that hypermethylation is an important mechanism in inactivation of tumor suppressor genes.
The predominent histology of CA esophagus in Hong Kong is squamous cell carcinoma which is different from the adenocarcinoma which is more commonly seen in the West. We studied the genetic basis of carcinogenesis of squamous cell carcinoma of esophagus. We showed that chromosomal inbalance is common in CA esophagus and identify a number of areas which would habor novel oncogenes or tumor suppressor genes. We identify and characterize a novel tumor suppressor gene UPK1A in CA esophagus and found miRNA to be important in carcinogenesis. In clinical case management, we worked closely with the surgeons in multidisciplinary and multimodality treatment. Most cases are treated with pre-operative chemoradiation and then surgery. We aim to identify biomarkers which will predict response to pre-operative chemoradiotherapy.
Prof. Kwong also has a long standing interest in studying radiation complications like hearing loss, temporal lobe necrosis and xerostomia after radiotherapy and the ways to reduce such complications. We study advanced radiotherapy techniques like intensity modulated radiotherapy, adaptive radiotherapy and stereotactic body radiotherapy and promote their use of in clinical practice.
|Awardees||Award Date||Honours / Awards / Prizes||Category|
|2018-12-01||Research Output Prize 2019. A comprehensive human gastric cancer organoid biobank captures tumor subtype heterogeneity and enables therapeutic screening. Cell Stem Cell, 23, 2018.: The University of Hong Kong||Research Achievement|
|2008-07-01||2008 Research Output Prize/Faculty Outstanding Research Output Award: The University of Hong Kong||Research Achievement|
|2010-10-30||Investigation of intratumoral heterogeneity in nasopharyngeal carcinoma: a distinct role of PET-CT from MRI: Best Poster Award at 18th Annual Scientific Meeting of Hong Kong College of Radiologists, Hong Kong, 30-31 October 2010||Others|
|2009-11-01||Young Investigator Award In Psychosocial Oncology : Higher Education And Younger Age Are Associated With Better Understanding Of Clinical Trials Among Hong Kong Cancer Patients: 16th Hong Kong International Cancer Congress & 6th Annual Meeting Centre For Cancer Research||Research Achievement|
|2012-08-31||General Research Fund (GRF) 2012-13: HKU 768312M. Amount: HK$ 1,169,000: General Research Fund (GRF)||Research Achievement|
|Term Period||Position||Professional Societies|
|2019-2020||President||Hong Kong Head and Neck Society|
|2012-2018||Chairman||Hong Kong NPC Study Group|
|2019||Organising and Scientific Committee Chair||Trisociety Head and Neck Meeting|
|2000-now||Member||International Society for Diseases of the Esophagus|
|2011||Scientific Committee of IAOO 3rd world congress 2011||The International Academy of oral Oncology|
|2011||Scientific Committee||Trisociety Head and Neck Oncology Meeting|
|1996-now||Member||Hong Kong Society of Radiation Oncology and Oncology|
|1996-now||Member||Hong Kong Paediatric Haematology and Oncology Study Group|
|2000-now||Member||Society of Clinical Oncology|
|1996-now||Member||Hong Kong Anti-Cancer Society|
|1999-now||Member||Hong Kong Nasopharyngeal Carcinoma Study Group|
|2010-now||Expert member in the Panel for Head and Neck Cancer and Musculoskeletal||Hong Kong Regional TNM Cancer Staging Subcommittee|
|2005-now||Member||American Society for Therapeutic Radiology and Oncology|
|1996-now||Fellow||Hong Kong Academy of Medicine|
|1996-now, 2000-2006||Member, Honaonary treasurer, President||Hong Kong Head and Neck Society|
|1996-now, 1999-2016, 2005-now, 2010-now, 2013||Fellow, Scientific Committee and membership committee, part II tutor, Examiner, Council Member||Hong Kong College of Radiologists|
|1993-now||Fellow||Royal College of Radiologists|
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