Understanding the evolution and interspecies transmission of betacoronaviruses by structural and biophysical approaches
Grant Data
Project Title
Understanding the evolution and interspecies transmission of betacoronaviruses by structural and biophysical approaches
Principal Investigator
Professor Yuen, Kwok Yung
(Principal Investigator (PI))
Co-Investigator(s)
Professor Gao George Fu
(Co-principal investigator)
Dr Lu Guangwen
(Co-Investigator)
Professor Lau Susanna Kar Pui
(Co-Investigator)
Dr Chan Jasper Fuk Woo
(Co-Investigator)
Professor Woo Patrick Chiu Yat
(Co-Investigator)
Dr Yan Jinghua
(Co-Investigator)
Dr Qi Jianxun
(Co-Investigator)
Duration
48
Start Date
2015-01-01
Amount
1098911
Conference Title
Understanding the evolution and interspecies transmission of betacoronaviruses by structural and biophysical approaches
Presentation Title
Keywords
batacoronavirus, evolution, receptor, spike, structure, transmission
Discipline
Structural Biology,Infection/Parasitology
HKU Project Code
N_HKU728/14
Grant Type
NSFC/RGC Joint Research Scheme
Funding Year
2014
Status
Completed
Objectives
1) To understand the evolution and interspecies transmission of betacoronaviruses (βCoVs) by identifying and characterizing the structural and functional features of their Spike protein variants identified in our bat surveillance program in mainland China and Hong Kong. 2) To identify and characterize the receptor-recognition of representative βCoVs that are of clinical importance to human or animals, such as human CoV-HKU1 and CoV-HKU9, by cocrystallization and protein-binding assays.
All Publications
| Title | Author(s) | Issue Date | Views | |
|---|---|---|---|---|
Middle East respiratory syndrome coronavirus and bat coronavirus HKU9 both can utilize GRP78 for attachment onto host cells Journal:Journal of Biological Chemistry | 2018 |