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- Publisher Website: 10.1002/pd.387
- Scopus: eid_2-s2.0-0036289563
- PMID: 12116317
- WOS: WOS:000176383000017
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Article: Attitude of at-risk subjects towards preimplantation genetic diagnosis of α- and β-thalassaemias in Hong Kong
Title | Attitude of at-risk subjects towards preimplantation genetic diagnosis of α- and β-thalassaemias in Hong Kong |
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Authors | |
Keywords | Asians Attitude Preimplantation diagnosis Thalassaemia |
Issue Date | 2002 |
Publisher | John Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/2252 |
Citation | Prenatal Diagnosis, 2002, v. 22 n. 6, p. 508-511 How to Cite? |
Abstract | Objectives: The aim of the study was to assess whether preimplantation genetic diagnosis (PGD) was an acceptable alternative to prenatal diagnosis in couples at risk of giving birth to a child with α- or β-thalassaemia in an Asian population. Methods: An information leaflet was distributed to the women at risk. They were asked to complete a questionnaire after having an interview with a designated investigator. Results: A total of 141 valid questionnaires were analysed; 82.3%: of the women considered PGD either the same or better than conventional prenatal diagnosis. Women with an affected child or a subfertility problem were more willing to accept PGD and to undergo this procedure in their future pregnancies. Their main concern about PGD was damage to the embryo during the PGD procedure. The most important perceived advantage of PGD was avoidance of termination of an affected pregnancy. Conclusions: PGD is an acceptable alternative to conventional prenatal diagnosis in women at risk of giving birth to a child with α- or β-thalassaemia in an Asian population. This is particularly true in women with a subfertility problem and in women who already have an affected child. Copyright © 2002 John Wiley & Sons, Ltd. |
Persistent Identifier | http://hdl.handle.net/10722/173261 |
ISSN | 2023 Impact Factor: 2.7 2023 SCImago Journal Rankings: 0.986 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Pui, WH | en_HK |
dc.contributor.author | Yung, HL | en_HK |
dc.contributor.author | Chen, M | en_HK |
dc.contributor.author | Tang, MHY | en_HK |
dc.contributor.author | Yeung, WSB | en_HK |
dc.contributor.author | Ng, EHY | en_HK |
dc.contributor.author | Pak, CH | en_HK |
dc.date.accessioned | 2012-10-30T06:28:52Z | - |
dc.date.available | 2012-10-30T06:28:52Z | - |
dc.date.issued | 2002 | en_HK |
dc.identifier.citation | Prenatal Diagnosis, 2002, v. 22 n. 6, p. 508-511 | en_HK |
dc.identifier.issn | 0197-3851 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/173261 | - |
dc.description.abstract | Objectives: The aim of the study was to assess whether preimplantation genetic diagnosis (PGD) was an acceptable alternative to prenatal diagnosis in couples at risk of giving birth to a child with α- or β-thalassaemia in an Asian population. Methods: An information leaflet was distributed to the women at risk. They were asked to complete a questionnaire after having an interview with a designated investigator. Results: A total of 141 valid questionnaires were analysed; 82.3%: of the women considered PGD either the same or better than conventional prenatal diagnosis. Women with an affected child or a subfertility problem were more willing to accept PGD and to undergo this procedure in their future pregnancies. Their main concern about PGD was damage to the embryo during the PGD procedure. The most important perceived advantage of PGD was avoidance of termination of an affected pregnancy. Conclusions: PGD is an acceptable alternative to conventional prenatal diagnosis in women at risk of giving birth to a child with α- or β-thalassaemia in an Asian population. This is particularly true in women with a subfertility problem and in women who already have an affected child. Copyright © 2002 John Wiley & Sons, Ltd. | en_HK |
dc.language | eng | en_US |
dc.publisher | John Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/2252 | en_HK |
dc.relation.ispartof | Prenatal Diagnosis | en_HK |
dc.rights | Prenatal Diagnosis. Copyright © John Wiley & Sons Ltd. | - |
dc.subject | Asians | en_HK |
dc.subject | Attitude | en_HK |
dc.subject | Preimplantation diagnosis | en_HK |
dc.subject | Thalassaemia | en_HK |
dc.subject.mesh | Adult | en_US |
dc.subject.mesh | Attitude | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Fertilization In Vitro | en_US |
dc.subject.mesh | Genetic Predisposition To Disease | en_US |
dc.subject.mesh | Homozygote | en_US |
dc.subject.mesh | Hong Kong | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Pregnancy | en_US |
dc.subject.mesh | Preimplantation Diagnosis | en_US |
dc.subject.mesh | Prenatal Diagnosis | en_US |
dc.subject.mesh | Questionnaires | en_US |
dc.subject.mesh | Alpha-Thalassemia - Diagnosis - Genetics | en_US |
dc.subject.mesh | Beta-Thalassemia - Diagnosis - Genetics | en_US |
dc.title | Attitude of at-risk subjects towards preimplantation genetic diagnosis of α- and β-thalassaemias in Hong Kong | en_HK |
dc.type | Article | en_HK |
dc.identifier.email | Tang, MHY: mhytang@hkucc.hku.hk | en_HK |
dc.identifier.email | Yeung, WSB: wsbyeung@hkucc.hku.hk | en_HK |
dc.identifier.email | Ng, EHY: nghye@hku.hk | en_HK |
dc.identifier.email | Pak, CH: pcho@hku.hk | en_HK |
dc.identifier.authority | Tang, MHY=rp01701 | en_HK |
dc.identifier.authority | Yeung, WSB=rp00331 | en_HK |
dc.identifier.authority | Ng, EHY=rp00426 | en_HK |
dc.identifier.authority | Pak, CH=rp00325 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1002/pd.387 | en_HK |
dc.identifier.pmid | 12116317 | - |
dc.identifier.scopus | eid_2-s2.0-0036289563 | en_HK |
dc.identifier.hkuros | 68488 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0036289563&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 22 | en_HK |
dc.identifier.issue | 6 | en_HK |
dc.identifier.spage | 508 | en_HK |
dc.identifier.epage | 511 | en_HK |
dc.identifier.isi | WOS:000176383000017 | - |
dc.publisher.place | United Kingdom | en_HK |
dc.identifier.scopusauthorid | Pui, WH=23109366000 | en_HK |
dc.identifier.scopusauthorid | Yung, HL=7202563903 | en_HK |
dc.identifier.scopusauthorid | Chen, M=26028797000 | en_HK |
dc.identifier.scopusauthorid | Tang, MHY=8943401300 | en_HK |
dc.identifier.scopusauthorid | Yeung, WSB=7102370745 | en_HK |
dc.identifier.scopusauthorid | Ng, EHY=35238184300 | en_HK |
dc.identifier.scopusauthorid | Pak, CH=7402211440 | en_HK |
dc.identifier.issnl | 0197-3851 | - |