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Conference Paper: Assessment of systemic inflammation in osteoarthritis patients by testing fatty-acid-binding protein 4 and adiponectin in plasma
Title | Assessment of systemic inflammation in osteoarthritis patients by testing fatty-acid-binding protein 4 and adiponectin in plasma |
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Authors | |
Issue Date | 2013 |
Publisher | Hong Kong Academy of Medicine Press. |
Citation | The 33rd Annual Congress of the Hong Kong Orthopaedic Association (HKOA 2013), Hong Kong, China, 23-24 November 2013. In Conference Abstracts, 2013, p. 21, abstract no. 2.9 How to Cite? |
Abstract | Introduction: Obesity not only increases risk of osteoarthritis (OA) in weight-bearing but also non–weight-bearing joints,
indicating systemic mediators involved. It was recently reported that inflammation is involved in the pathogenesis of
OA. Fatty-acid-binding protein 4 (FABP-4) has been described as a novel adipokine, playing a pro-inflammatory role in
inflammatory pathways. Adiponectin has been widely reported with an anti-inflammatory function. This study aimed to
evaluate the relationship of plasma levels of FABP4 and adiponectin and the presence of OA.
Materials and Methods: For FABP4 concentration determination, a total of 231 Chinese subjects (77 males and 154 females)
were recruited, including 141 OA cases and 90 community-based controls. Circulating levels of FABP4 and adiponectin
were determined using enzyme-linked immunosorbent assay (AIS, HKU).
Results: The mean (± standard deviation) FABP4 levels in OA patients (16.6 ± 15.5 ng/mL) were significantly higher than
non-OA subjects (12.6 ± 10.1 ng/mL, p = 0.0453). Female subjects had significantly higher mean circulating levels of FABP4
than male counterparts both in case group (16.1 ± 14.9 ng/mL vs. 8.6 ± 7.3 ng/mL, p < 0.0001) and control group (17.1 ±
11.6 ng/mL vs. 7.9 ± 5.2 ng/mL, p < 0.0001). There were no significant differences of circulating levels of FABP4 neither
between male cases and male controls (p = 0.765) nor female cases and female controls (p = 0.261).
Discussion and Conclusion: Female subjects had significantly higher concentrations of FABP-4 in plasma. |
Description | Conference Theme: Defying the Aging Spine Concurrent Free Papers 2: Basic Science / General Orthopaedics |
Persistent Identifier | http://hdl.handle.net/10722/203752 |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Li, T | en_US |
dc.contributor.author | Yan, CH | en_US |
dc.contributor.author | Xu, A | en_US |
dc.contributor.author | Song, Y | en_US |
dc.contributor.author | Chiu, PKY | en_US |
dc.date.accessioned | 2014-09-19T16:40:49Z | - |
dc.date.available | 2014-09-19T16:40:49Z | - |
dc.date.issued | 2013 | en_US |
dc.identifier.citation | The 33rd Annual Congress of the Hong Kong Orthopaedic Association (HKOA 2013), Hong Kong, China, 23-24 November 2013. In Conference Abstracts, 2013, p. 21, abstract no. 2.9 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/203752 | - |
dc.description | Conference Theme: Defying the Aging Spine | - |
dc.description | Concurrent Free Papers 2: Basic Science / General Orthopaedics | - |
dc.description.abstract | Introduction: Obesity not only increases risk of osteoarthritis (OA) in weight-bearing but also non–weight-bearing joints, indicating systemic mediators involved. It was recently reported that inflammation is involved in the pathogenesis of OA. Fatty-acid-binding protein 4 (FABP-4) has been described as a novel adipokine, playing a pro-inflammatory role in inflammatory pathways. Adiponectin has been widely reported with an anti-inflammatory function. This study aimed to evaluate the relationship of plasma levels of FABP4 and adiponectin and the presence of OA. Materials and Methods: For FABP4 concentration determination, a total of 231 Chinese subjects (77 males and 154 females) were recruited, including 141 OA cases and 90 community-based controls. Circulating levels of FABP4 and adiponectin were determined using enzyme-linked immunosorbent assay (AIS, HKU). Results: The mean (± standard deviation) FABP4 levels in OA patients (16.6 ± 15.5 ng/mL) were significantly higher than non-OA subjects (12.6 ± 10.1 ng/mL, p = 0.0453). Female subjects had significantly higher mean circulating levels of FABP4 than male counterparts both in case group (16.1 ± 14.9 ng/mL vs. 8.6 ± 7.3 ng/mL, p < 0.0001) and control group (17.1 ± 11.6 ng/mL vs. 7.9 ± 5.2 ng/mL, p < 0.0001). There were no significant differences of circulating levels of FABP4 neither between male cases and male controls (p = 0.765) nor female cases and female controls (p = 0.261). Discussion and Conclusion: Female subjects had significantly higher concentrations of FABP-4 in plasma. | - |
dc.language | eng | en_US |
dc.publisher | Hong Kong Academy of Medicine Press. | - |
dc.relation.ispartof | Annual Congress of the Hong Kong Orthopaedic Association, HKOA 2013 | en_US |
dc.relation.ispartof | 香港骨科醫學會第三十三屇週年會議 | - |
dc.title | Assessment of systemic inflammation in osteoarthritis patients by testing fatty-acid-binding protein 4 and adiponectin in plasma | en_US |
dc.type | Conference_Paper | en_US |
dc.identifier.email | Yan, CH: yanchoi@hku.hk | en_US |
dc.identifier.email | Xu, A: amxu@hkucc.hku.hk | en_US |
dc.identifier.email | Song, Y: songy@hku.hk | en_US |
dc.identifier.email | Chiu, PKY: pkychiu@hkucc.hku.hk | en_US |
dc.identifier.authority | Yan, CH=rp00303 | en_US |
dc.identifier.authority | Xu, A=rp00485 | en_US |
dc.identifier.authority | Song, Y=rp00488 | en_US |
dc.identifier.authority | Chiu, PKY=rp00379 | en_US |
dc.identifier.hkuros | 235763 | en_US |
dc.identifier.hkuros | 240262 | - |
dc.identifier.spage | 21, abstract no. 2.9 | en_US |
dc.identifier.epage | 21, abstract no. 2.9 | en_US |
dc.publisher.place | Hong Kong | - |