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Conference Paper: The enzymatic mechanism mediating the breakdown of glycogen in hypoxic tumor cells
| Title | The enzymatic mechanism mediating the breakdown of glycogen in hypoxic tumor cells |
|---|---|
| Authors | |
| Issue Date | 2014 |
| Citation | The 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Hong Kong, 14 June 2014. In Program Booklet, 2014, p. 30, abstract no. 35 How to Cite? |
| Abstract | Glycogen has been recently implicated as a major source of metabolic fuel for hypoxic tumor cells. The biochemical mechanism underlying the breakdown of glycogen to produce the substrate for glycolysis though is not fully understood. The aim of this study is to demonstrate the potential role of glycogen phosphorylase or α-glucosidase in mediating breakdown of intracellular glycogen in hypoxic tumor cells. The deprivation of glucose in normoxic tumor cells over a period of 6 hours resulted in marked reduction of intracellular glycogen level. Imposing hypoxia (1% O2) on these cells during ... |
| Description | Poster presentation - Theme 2: Cancer & other diseases |
| Persistent Identifier | http://hdl.handle.net/10722/203857 |
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Mung, KL | en_US |
| dc.contributor.author | Wong, NS | en_US |
| dc.date.accessioned | 2014-09-19T16:42:20Z | - |
| dc.date.available | 2014-09-19T16:42:20Z | - |
| dc.date.issued | 2014 | en_US |
| dc.identifier.citation | The 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Hong Kong, 14 June 2014. In Program Booklet, 2014, p. 30, abstract no. 35 | en_US |
| dc.identifier.uri | http://hdl.handle.net/10722/203857 | - |
| dc.description | Poster presentation - Theme 2: Cancer & other diseases | - |
| dc.description.abstract | Glycogen has been recently implicated as a major source of metabolic fuel for hypoxic tumor cells. The biochemical mechanism underlying the breakdown of glycogen to produce the substrate for glycolysis though is not fully understood. The aim of this study is to demonstrate the potential role of glycogen phosphorylase or α-glucosidase in mediating breakdown of intracellular glycogen in hypoxic tumor cells. The deprivation of glucose in normoxic tumor cells over a period of 6 hours resulted in marked reduction of intracellular glycogen level. Imposing hypoxia (1% O2) on these cells during ... | - |
| dc.language | eng | en_US |
| dc.relation.ispartof | Hong Kong Inter-University Biochemistry Postgraduate Symposium | en_US |
| dc.title | The enzymatic mechanism mediating the breakdown of glycogen in hypoxic tumor cells | en_US |
| dc.type | Conference_Paper | en_US |
| dc.identifier.email | Wong, NS: nswong@hku.hk | en_US |
| dc.identifier.authority | Wong, NS=rp00340 | en_US |
| dc.description.nature | postprint | - |
| dc.identifier.hkuros | 240364 | en_US |
| dc.identifier.spage | 30, abstract no. 35 | - |
| dc.identifier.epage | 30, abstract no. 35 | - |