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Conference Paper: Gender differences in correlates of neurocognition and functioning in first-episode psychosis
Title | Gender differences in correlates of neurocognition and functioning in first-episode psychosis |
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Authors | |
Issue Date | 2014 |
Publisher | Hong Kong Academy of Medicine Press. The Journal's web site is located at http://easap.asia/index.htm |
Citation | The 2014 Regional Congress of the World Psychiatric Association (WPA), Hong Kong, 12-14 December 2014. In East Asian Archives of Psychiatry, 2014, v. 24 n. 4 suppl., p. 102, abstract G13 How to Cite? |
Abstract | OBJECTIVE: Gender differences are extensively studied in schizophrenia, with distinct profiles in demography, symptoms, and prognosis. However, findings in cognitive functioning have been mixed.1,2 This study examined sex differences in associations between demographics, symptoms and cognition, and investigated predictors of cognition in a large sample of patients with first-episode psychosis (FEP) in Hong Kong. METHODS: A total of 360 adult-onset FEP patients were administered a comprehensive battery of neurocognitive tests upon admission into a specialised early intervention service. Detailed demographic, clinical, and functioning data were also collected. RESULTS: Bivariate correlation analysis showed that duration of untreated psychosis was significantly associated with affective symptom severity in men. Memory and working memory were more significantly associated with onset age, negative symptoms, and side-effects in women. Processing speed was associated with antipsychotic dosage in men and side-effects in women. Selective attention was associated with positive and negative symptoms in women, and onset age and educational level in men. Executive function was associated with onset age and positive symptoms in women. All cognitive domains were significantly associated with educational level and functioning in both genders. Duration of untreated psychosis and disorganisation had no significant correlations. Linear regression analysis demonstrated that negative symptoms were predictive of cognition in both genders, while positive symptoms, medication side-effects, and affective symptoms were predictors in men and women, respectively. CONCLUSION: The data suggest that although there are common correlates, considerable heterogeneity exists in associations of symptoms and cognitive performance in men and women. Findings can inform more gender-specific tailoring of clinical treatment plans, such as cognitive remediation therapy. |
Description | Congress Theme: Yin and Yang of Mental Health in Asia - Balancing Polarities Category G – Schizophrenia and Psychotic Disorders: no. G13 |
Persistent Identifier | http://hdl.handle.net/10722/214257 |
ISSN | 2023 SCImago Journal Rankings: 0.364 |
DC Field | Value | Language |
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dc.contributor.author | Li, A | - |
dc.contributor.author | Hui, CLM | - |
dc.contributor.author | Chang, WC | - |
dc.contributor.author | Chan, SKW | - |
dc.contributor.author | Lee, EHM | - |
dc.contributor.author | Chen, EYH | - |
dc.date.accessioned | 2015-08-21T11:05:01Z | - |
dc.date.available | 2015-08-21T11:05:01Z | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | The 2014 Regional Congress of the World Psychiatric Association (WPA), Hong Kong, 12-14 December 2014. In East Asian Archives of Psychiatry, 2014, v. 24 n. 4 suppl., p. 102, abstract G13 | - |
dc.identifier.issn | 2078-9947 | - |
dc.identifier.uri | http://hdl.handle.net/10722/214257 | - |
dc.description | Congress Theme: Yin and Yang of Mental Health in Asia - Balancing Polarities | - |
dc.description | Category G – Schizophrenia and Psychotic Disorders: no. G13 | - |
dc.description.abstract | OBJECTIVE: Gender differences are extensively studied in schizophrenia, with distinct profiles in demography, symptoms, and prognosis. However, findings in cognitive functioning have been mixed.1,2 This study examined sex differences in associations between demographics, symptoms and cognition, and investigated predictors of cognition in a large sample of patients with first-episode psychosis (FEP) in Hong Kong. METHODS: A total of 360 adult-onset FEP patients were administered a comprehensive battery of neurocognitive tests upon admission into a specialised early intervention service. Detailed demographic, clinical, and functioning data were also collected. RESULTS: Bivariate correlation analysis showed that duration of untreated psychosis was significantly associated with affective symptom severity in men. Memory and working memory were more significantly associated with onset age, negative symptoms, and side-effects in women. Processing speed was associated with antipsychotic dosage in men and side-effects in women. Selective attention was associated with positive and negative symptoms in women, and onset age and educational level in men. Executive function was associated with onset age and positive symptoms in women. All cognitive domains were significantly associated with educational level and functioning in both genders. Duration of untreated psychosis and disorganisation had no significant correlations. Linear regression analysis demonstrated that negative symptoms were predictive of cognition in both genders, while positive symptoms, medication side-effects, and affective symptoms were predictors in men and women, respectively. CONCLUSION: The data suggest that although there are common correlates, considerable heterogeneity exists in associations of symptoms and cognitive performance in men and women. Findings can inform more gender-specific tailoring of clinical treatment plans, such as cognitive remediation therapy. | - |
dc.language | eng | - |
dc.publisher | Hong Kong Academy of Medicine Press. The Journal's web site is located at http://easap.asia/index.htm | - |
dc.relation.ispartof | East Asian Archives of Psychiatry | - |
dc.relation.ispartof | 東亞精神科學志 | - |
dc.rights | East Asian Archives of Psychiatry. Copyright © Hong Kong Academy of Medicine Press. | - |
dc.title | Gender differences in correlates of neurocognition and functioning in first-episode psychosis | - |
dc.type | Conference_Paper | - |
dc.identifier.email | Hui, CLM: christyh@hkucc.hku.hk | - |
dc.identifier.email | Chang, WC: changwc@hku.hk | - |
dc.identifier.email | Chan, SKW: kwsherry@hku.hk | - |
dc.identifier.email | Lee, EHM: edwinlhm@hku.hk | - |
dc.identifier.email | Chen, EYH: eyhchen@hku.hk | - |
dc.identifier.authority | Hui, CLM=rp01993 | - |
dc.identifier.authority | Chang, WC=rp01465 | - |
dc.identifier.authority | Chan, SKW=rp00539 | - |
dc.identifier.authority | Lee, EHM=rp01575 | - |
dc.identifier.authority | Chen, EYH=rp00392 | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.hkuros | 249136 | - |
dc.identifier.volume | 24 | - |
dc.identifier.issue | 4 suppl. | - |
dc.identifier.spage | 102, abstract G13 | - |
dc.identifier.epage | 102, abstract G13 | - |
dc.publisher.place | Hong Kong | - |
dc.identifier.issnl | 2078-9947 | - |