File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1016/j.clon.2016.05.004
- Scopus: eid_2-s2.0-84971634956
- PMID: 27235379
- WOS: WOS:000379565500005
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: Dosimetric Predictors of Hypothyroidism After Radical Intensity-modulated Radiation Therapy for Non-metastatic Nasopharyngeal Carcinoma
Title | Dosimetric Predictors of Hypothyroidism After Radical Intensity-modulated Radiation Therapy for Non-metastatic Nasopharyngeal Carcinoma |
---|---|
Authors | |
Keywords | Dosimetric predictors Hypothyroidism Intensity-modulated radiation therapy Nasopharyngeal carcinoma |
Issue Date | 2016 |
Publisher | WB Saunders Co Ltd. The Journal's web site is located at http://www.elsevier.com/locate/clon |
Citation | Clinical Oncology, 2016, v. 28 n. 8, p. e52-e60 How to Cite? |
Abstract | Aims:
To investigate dosimetric predictors of hypothyroidism after radical intensity-modulated radiation therapy (IMRT) for non-metastatic nasopharyngeal carcinoma (NPC).
Materials and methods:
Patients with non-metastatic NPC treated with radical IMRT from 2008 to 2013 were reviewed. Serum thyroid function tests before and after IMRT were regularly monitored. Univariable and multivariable analyses were carried out for predictors of biochemical and clinical hypothyroidism.
Results:
In total, 149 patients were recruited. After a median follow-up duration of 3.1 years, 33 (22.1%) and 21 (14.1%) patients developed biochemical and clinical hypothyroidism, respectively. Eight (24.2%) patients who had biochemical hypothyroidism developed clinical hypothyroidism later. Univariable and multivariable analyses revealed that the volume of the thyroid (P = 0.002, multivariable), VS60 (the absolute thyroid volume spared from 60 Gy or less) (P < 0.001, multivariable) and VS45 (P < 0.001, multivariable) of the thyroid were significant predictors of biochemical hypothyroidism. The freedom from biochemical hypothyroidism was longer for those whose VS60 ≥ 10 cm3 (mean 90.9 versus 62.6 months; P < 0.001) and VS45 ≥ 5 cm3 (mean 91.9 versus 65.2 months; P = 0.001). Similarly multivariable analyses revealed that VS60 (P = 0.001) and VS45 (P = 0.003) were significant predictors of clinical hypothyroidism. The freedom from clinical hypothyroidism was longer for those whose VS60 ≥ 10 cm3 (91.5 versus 73.3 months; P = 0.002) and VS45 ≥ 5 cm3 (91.5 versus 75.9 months; P = 0.007).
Conclusions:
VS60 and VS45 of the thyroid should be considered important dose constraints against hypothyroidism without compromising target coverage during IMRT optimisation for NPC. |
Persistent Identifier | http://hdl.handle.net/10722/227211 |
ISSN | 2023 Impact Factor: 3.2 2023 SCImago Journal Rankings: 0.907 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, V | - |
dc.contributor.author | Chan, SY | - |
dc.contributor.author | Choi, CW | - |
dc.contributor.author | Kwong, D | - |
dc.contributor.author | Lam, KO | - |
dc.contributor.author | Tong, CC | - |
dc.contributor.author | Sze, CK | - |
dc.contributor.author | Ng, S | - |
dc.contributor.author | Leung, TW | - |
dc.contributor.author | Lee, A | - |
dc.date.accessioned | 2016-07-18T09:09:06Z | - |
dc.date.available | 2016-07-18T09:09:06Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | Clinical Oncology, 2016, v. 28 n. 8, p. e52-e60 | - |
dc.identifier.issn | 0936-6555 | - |
dc.identifier.uri | http://hdl.handle.net/10722/227211 | - |
dc.description.abstract | Aims: To investigate dosimetric predictors of hypothyroidism after radical intensity-modulated radiation therapy (IMRT) for non-metastatic nasopharyngeal carcinoma (NPC). Materials and methods: Patients with non-metastatic NPC treated with radical IMRT from 2008 to 2013 were reviewed. Serum thyroid function tests before and after IMRT were regularly monitored. Univariable and multivariable analyses were carried out for predictors of biochemical and clinical hypothyroidism. Results: In total, 149 patients were recruited. After a median follow-up duration of 3.1 years, 33 (22.1%) and 21 (14.1%) patients developed biochemical and clinical hypothyroidism, respectively. Eight (24.2%) patients who had biochemical hypothyroidism developed clinical hypothyroidism later. Univariable and multivariable analyses revealed that the volume of the thyroid (P = 0.002, multivariable), VS60 (the absolute thyroid volume spared from 60 Gy or less) (P < 0.001, multivariable) and VS45 (P < 0.001, multivariable) of the thyroid were significant predictors of biochemical hypothyroidism. The freedom from biochemical hypothyroidism was longer for those whose VS60 ≥ 10 cm3 (mean 90.9 versus 62.6 months; P < 0.001) and VS45 ≥ 5 cm3 (mean 91.9 versus 65.2 months; P = 0.001). Similarly multivariable analyses revealed that VS60 (P = 0.001) and VS45 (P = 0.003) were significant predictors of clinical hypothyroidism. The freedom from clinical hypothyroidism was longer for those whose VS60 ≥ 10 cm3 (91.5 versus 73.3 months; P = 0.002) and VS45 ≥ 5 cm3 (91.5 versus 75.9 months; P = 0.007). Conclusions: VS60 and VS45 of the thyroid should be considered important dose constraints against hypothyroidism without compromising target coverage during IMRT optimisation for NPC. | - |
dc.language | eng | - |
dc.publisher | WB Saunders Co Ltd. The Journal's web site is located at http://www.elsevier.com/locate/clon | - |
dc.relation.ispartof | Clinical Oncology | - |
dc.subject | Dosimetric predictors | - |
dc.subject | Hypothyroidism | - |
dc.subject | Intensity-modulated radiation therapy | - |
dc.subject | Nasopharyngeal carcinoma | - |
dc.title | Dosimetric Predictors of Hypothyroidism After Radical Intensity-modulated Radiation Therapy for Non-metastatic Nasopharyngeal Carcinoma | - |
dc.type | Article | - |
dc.identifier.email | Lee, V: vhflee@hku.hk | - |
dc.identifier.email | Choi, CW: hcchoi@hku.hk | - |
dc.identifier.email | Kwong, D: dlwkwong@hku.hk | - |
dc.identifier.email | Lam, KO: lamkaon@hku.hk | - |
dc.identifier.email | Tong, CC: tccz01@hku.hk | - |
dc.identifier.email | Sze, CK: henrysze@graduate.hku.hk | - |
dc.identifier.email | Leung, TW: ltw920@hkucc.hku.hk | - |
dc.identifier.email | Lee, A: awmlee@hkucc.hku.hk | - |
dc.identifier.authority | Lee, V=rp00264 | - |
dc.identifier.authority | Choi, CW=rp02815 | - |
dc.identifier.authority | Kwong, D=rp00414 | - |
dc.identifier.authority | Lam, KO=rp01501 | - |
dc.identifier.authority | Sze, CK=rp01697 | - |
dc.identifier.authority | Lee, A=rp02056 | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/j.clon.2016.05.004 | - |
dc.identifier.pmid | 27235379 | - |
dc.identifier.scopus | eid_2-s2.0-84971634956 | - |
dc.identifier.hkuros | 258807 | - |
dc.identifier.volume | 28 | - |
dc.identifier.issue | 8 | - |
dc.identifier.spage | e52 | - |
dc.identifier.epage | e60 | - |
dc.identifier.isi | WOS:000379565500005 | - |
dc.publisher.place | United Kingdom | - |