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Article: Neurotrophin-3-Loaded Multichannel Nanofibrous Scaffolds Promoted Anti-Inflammation, Neuronal Differentiation, and Functional Recovery after Spinal Cord Injury

TitleNeurotrophin-3-Loaded Multichannel Nanofibrous Scaffolds Promoted Anti-Inflammation, Neuronal Differentiation, and Functional Recovery after Spinal Cord Injury
Authors
Keywordsspinal cord injury
multichannel nanofibrous scaffold
neurotrophin-3
gelatin
neural stem cell
Issue Date2020
PublisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/toc/abseba/current
Citation
ACS Biomaterials Science & Engineering, 2020, v. 6 n. 2, p. 1228-1238 How to Cite?
AbstractThe clinical therapeutics for nerve tissue regeneration and functional recovery after spinal cord injury (SCI) are very limited because of the complex biological processes and inhibitory microenvironment. Advanced biomaterials are highly desired to avoid severe secondary damage and provide guidance for axonal regrowth. Multichannel nanofibrous scaffolds were modified with gelatin and cross-linked by genipin. The gelatin-coated nanofibers exhibited strong binding affinity with neurotrophin-3, which underwent a well-controlled release and highly promoted neuronal differentiation and synapse formation of the seeded neural stem cells. The nanofibrous scaffolds fabricated by combinatorial biomaterials were implanted into complete transected spinal cords in rats. Not only were the inflammatory responses and collagen/astrocytic scar formation limited, but the functional neurons and remyelination were facilitated postsurgery, leading to highly improved functional restoration. This nanofibrous scaffold with high specific surface area can be easily modified with biomolecules, which was proven to be effective for nerve regeneration after transected SCI, and provided a springboard for advanced scaffold design in clinical applications.
Persistent Identifierhttp://hdl.handle.net/10722/290618
ISSN
2019 Impact Factor: 4.152

 

DC FieldValueLanguage
dc.contributor.authorSUN, X-
dc.contributor.authorZHANG, C-
dc.contributor.authorXU, J-
dc.contributor.authorZHAI, H-
dc.contributor.authorLIU, S-
dc.contributor.authorXU, Y-
dc.contributor.authorHu, Y-
dc.contributor.authorLONG, H-
dc.contributor.authorBAI, Y-
dc.contributor.authorQUAN, D-
dc.date.accessioned2020-11-02T05:44:45Z-
dc.date.available2020-11-02T05:44:45Z-
dc.date.issued2020-
dc.identifier.citationACS Biomaterials Science & Engineering, 2020, v. 6 n. 2, p. 1228-1238-
dc.identifier.issn2373-9878-
dc.identifier.urihttp://hdl.handle.net/10722/290618-
dc.description.abstractThe clinical therapeutics for nerve tissue regeneration and functional recovery after spinal cord injury (SCI) are very limited because of the complex biological processes and inhibitory microenvironment. Advanced biomaterials are highly desired to avoid severe secondary damage and provide guidance for axonal regrowth. Multichannel nanofibrous scaffolds were modified with gelatin and cross-linked by genipin. The gelatin-coated nanofibers exhibited strong binding affinity with neurotrophin-3, which underwent a well-controlled release and highly promoted neuronal differentiation and synapse formation of the seeded neural stem cells. The nanofibrous scaffolds fabricated by combinatorial biomaterials were implanted into complete transected spinal cords in rats. Not only were the inflammatory responses and collagen/astrocytic scar formation limited, but the functional neurons and remyelination were facilitated postsurgery, leading to highly improved functional restoration. This nanofibrous scaffold with high specific surface area can be easily modified with biomolecules, which was proven to be effective for nerve regeneration after transected SCI, and provided a springboard for advanced scaffold design in clinical applications.-
dc.languageeng-
dc.publisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/toc/abseba/current-
dc.relation.ispartofACS Biomaterials Science & Engineering-
dc.rightsThis document is the Accepted Manuscript version of a Published Work that appeared in final form in [JournalTitle], copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see [insert ACS Articles on Request author-directed link to Published Work, see http://pubs.acs.org/page/policy/articlesonrequest/index.html].-
dc.subjectspinal cord injury-
dc.subjectmultichannel nanofibrous scaffold-
dc.subjectneurotrophin-3-
dc.subjectgelatin-
dc.subjectneural stem cell-
dc.titleNeurotrophin-3-Loaded Multichannel Nanofibrous Scaffolds Promoted Anti-Inflammation, Neuronal Differentiation, and Functional Recovery after Spinal Cord Injury-
dc.typeArticle-
dc.identifier.emailHu, Y: yhud@hku.hk-
dc.identifier.authorityHu, Y=rp00432-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1021/acsbiomaterials.0c00023-
dc.identifier.scopuseid_2-s2.0-85079773924-
dc.identifier.hkuros317833-
dc.identifier.volume6-
dc.identifier.issue2-
dc.identifier.spage1228-
dc.identifier.epage1238-
dc.publisher.placeUnited States-

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