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Article: Recent Insights Into the Role of Immune Cells in Alcoholic Liver Disease

TitleRecent Insights Into the Role of Immune Cells in Alcoholic Liver Disease
Authors
Keywordsimmune cells
inflammation
alcoholic liver disease (ALD)
innate immunity
adaptive immunity
Issue Date2019
PublisherFrontiers Research Foundation. The Journal's web site is located at http://www.frontiersin.org/immunology
Citation
Frontiers in Immunology, 2019, v. 10, p. article no. 1328 How to Cite?
AbstractAccumulating clinical and experimental evidences have demonstrated that both innate and adaptive immunity are involved in the pathogenesis of alcoholic liver disease (ALD), in which the role of immunity is to fuel the inflammation and to drive the progression of ALD. Various immune cells are implicated in the pathogenesis of ALD. The activation of innate immune cells induced by alcohol and adaptive immune response triggered by oxidative modification of hepatic constituents facilitate the persistent hepatic inflammation. Meanwhile, the suppressed antigen-presenting capability of various innate immune cells and impaired function of T cells may consequently lead to an increased risk of infection in the patients with advanced ALD. In this review, we summarized the significant recent findings of immune cells participating in ALD. The pathways and molecules involved in the regulation of specific immune cells, and novel mediators protecting the liver from alcoholic injury via affecting these cells are particularly highlighted. This review aims to update the knowledge about immunity in the pathogenesis of ALD, which may facilitate to enhancement of currently available interventions for ALD treatment.
Persistent Identifierhttp://hdl.handle.net/10722/293649
ISSN
2019 Impact Factor: 5.085
2015 SCImago Journal Rankings: 2.810
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLi, S-
dc.contributor.authorTan, HY-
dc.contributor.authorWang, N-
dc.contributor.authorFeng, Y-
dc.contributor.authorWang, X-
dc.contributor.authorFeng, Y-
dc.date.accessioned2020-11-23T08:19:49Z-
dc.date.available2020-11-23T08:19:49Z-
dc.date.issued2019-
dc.identifier.citationFrontiers in Immunology, 2019, v. 10, p. article no. 1328-
dc.identifier.issn1664-3224-
dc.identifier.urihttp://hdl.handle.net/10722/293649-
dc.description.abstractAccumulating clinical and experimental evidences have demonstrated that both innate and adaptive immunity are involved in the pathogenesis of alcoholic liver disease (ALD), in which the role of immunity is to fuel the inflammation and to drive the progression of ALD. Various immune cells are implicated in the pathogenesis of ALD. The activation of innate immune cells induced by alcohol and adaptive immune response triggered by oxidative modification of hepatic constituents facilitate the persistent hepatic inflammation. Meanwhile, the suppressed antigen-presenting capability of various innate immune cells and impaired function of T cells may consequently lead to an increased risk of infection in the patients with advanced ALD. In this review, we summarized the significant recent findings of immune cells participating in ALD. The pathways and molecules involved in the regulation of specific immune cells, and novel mediators protecting the liver from alcoholic injury via affecting these cells are particularly highlighted. This review aims to update the knowledge about immunity in the pathogenesis of ALD, which may facilitate to enhancement of currently available interventions for ALD treatment.-
dc.languageeng-
dc.publisherFrontiers Research Foundation. The Journal's web site is located at http://www.frontiersin.org/immunology-
dc.relation.ispartofFrontiers in Immunology-
dc.rightsThis Document is Protected by copyright and was first published by Frontiers. All rights reserved. It is reproduced with permission.-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectimmune cells-
dc.subjectinflammation-
dc.subjectalcoholic liver disease (ALD)-
dc.subjectinnate immunity-
dc.subjectadaptive immunity-
dc.titleRecent Insights Into the Role of Immune Cells in Alcoholic Liver Disease-
dc.typeArticle-
dc.identifier.emailLi, S: lishaha@hku.hk-
dc.identifier.emailTan, HY: hyhtan@hku.hk-
dc.identifier.emailWang, N: ckwang@hku.hk-
dc.identifier.emailFeng, Y: yfeng@hku.hk-
dc.identifier.authorityWang, N=rp02075-
dc.identifier.authorityFeng, Y=rp00466-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.3389/fimmu.2019.01328-
dc.identifier.pmid31244862-
dc.identifier.pmcidPMC6581703-
dc.identifier.scopuseid_2-s2.0-85091482505-
dc.identifier.hkuros320044-
dc.identifier.volume10-
dc.identifier.spagearticle no. 1328-
dc.identifier.epagearticle no. 1328-
dc.identifier.isiWOS:000471194000003-
dc.publisher.placeSwitzerland-
dc.identifier.issnl1664-3224-

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