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Article: A randomized trial to compare the use of sublingual misoprostol with or without an additional 1 week course for the management of first trimester silent miscarriage
Title | A randomized trial to compare the use of sublingual misoprostol with or without an additional 1 week course for the management of first trimester silent miscarriage |
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Authors | |
Keywords | First trimester Miscarriage Misoprostol Sublingual |
Issue Date | 2006 |
Publisher | Oxford University Press. The Journal's web site is located at http://humrep.oxfordjournals.org/ |
Citation | Human Reproduction, 2006, v. 21 n. 1, p. 189-192 How to Cite? |
Abstract | Background: This randomized controlled trial compared the use of sublingual misoprostol with or without an additional 1 week course of sublingual misoprostol for the medical management of silent miscarriage. Methods: A total of 180 women who had silent miscarriage (<13 weeks) was given 600 μg of misoprostol every 3 h for a maximum of three doses. These women were randomized into two groups: (i) no extended course of misoprostol or (ii) an extended course of sublingual misoprostol 400 μg daily for 1 week. The primary outcome measure was complete miscarriage rate. Results: The success rates for complete miscarriage were similar in both groups (group 1: 92.2%; 95% CI: 86.1-97.5% and group 2: 93.2%; 95% CI: 84.6-96.8%). There were no serious complications. The incidence of diarrhoea was higher (P < 0.01) in the group with an extended course of sublingual misoprostol. Other side-effects were similar. Conclusion: Sublingual misoprostol is useful for the management of silent miscarriage. An additional 1 week course of sublingual misoprostol did not improve the success rate or shorten the duration of vaginal bleeding. Instead, it increased the incidence of diarrhoea. © The Author 2005. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. |
Persistent Identifier | http://hdl.handle.net/10722/87109 |
ISSN | 2023 Impact Factor: 6.0 2023 SCImago Journal Rankings: 1.852 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Tang, OS | en_HK |
dc.contributor.author | Ong, CYT | en_HK |
dc.contributor.author | Tse, KY | en_HK |
dc.contributor.author | Ng, EHY | en_HK |
dc.contributor.author | Lee, SWH | en_HK |
dc.contributor.author | Ho, PC | en_HK |
dc.date.accessioned | 2010-09-06T09:25:26Z | - |
dc.date.available | 2010-09-06T09:25:26Z | - |
dc.date.issued | 2006 | en_HK |
dc.identifier.citation | Human Reproduction, 2006, v. 21 n. 1, p. 189-192 | en_HK |
dc.identifier.issn | 0268-1161 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/87109 | - |
dc.description.abstract | Background: This randomized controlled trial compared the use of sublingual misoprostol with or without an additional 1 week course of sublingual misoprostol for the medical management of silent miscarriage. Methods: A total of 180 women who had silent miscarriage (<13 weeks) was given 600 μg of misoprostol every 3 h for a maximum of three doses. These women were randomized into two groups: (i) no extended course of misoprostol or (ii) an extended course of sublingual misoprostol 400 μg daily for 1 week. The primary outcome measure was complete miscarriage rate. Results: The success rates for complete miscarriage were similar in both groups (group 1: 92.2%; 95% CI: 86.1-97.5% and group 2: 93.2%; 95% CI: 84.6-96.8%). There were no serious complications. The incidence of diarrhoea was higher (P < 0.01) in the group with an extended course of sublingual misoprostol. Other side-effects were similar. Conclusion: Sublingual misoprostol is useful for the management of silent miscarriage. An additional 1 week course of sublingual misoprostol did not improve the success rate or shorten the duration of vaginal bleeding. Instead, it increased the incidence of diarrhoea. © The Author 2005. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. | en_HK |
dc.language | eng | en_HK |
dc.publisher | Oxford University Press. The Journal's web site is located at http://humrep.oxfordjournals.org/ | en_HK |
dc.relation.ispartof | Human Reproduction | en_HK |
dc.rights | Human Reproduction. Copyright © Oxford University Press. | en_HK |
dc.subject | First trimester | en_HK |
dc.subject | Miscarriage | en_HK |
dc.subject | Misoprostol | en_HK |
dc.subject | Sublingual | en_HK |
dc.title | A randomized trial to compare the use of sublingual misoprostol with or without an additional 1 week course for the management of first trimester silent miscarriage | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0268-1161&volume=21&issue=1&spage=189&epage=192&date=2006&atitle=A+randomized+trial+to+compare+the+use+of+sublingual+misoprostol+with+or+without+an+additional+1+week+course+for+the+management+of+first+trimester+silent+miscarriage | en_HK |
dc.identifier.email | Ong, CYT:cytong@hkucc.hku.hk | en_HK |
dc.identifier.email | Ng, EHY:nghye@hkucc.hku.hk | en_HK |
dc.identifier.email | Ho, PC:pcho@hku.hk | en_HK |
dc.identifier.authority | Ong, CYT=rp00482 | en_HK |
dc.identifier.authority | Ng, EHY=rp00426 | en_HK |
dc.identifier.authority | Ho, PC=rp00325 | en_HK |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1093/humrep/dei303 | en_HK |
dc.identifier.pmid | 16155071 | - |
dc.identifier.scopus | eid_2-s2.0-29144449258 | en_HK |
dc.identifier.hkuros | 120936 | en_HK |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-29144449258&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 21 | en_HK |
dc.identifier.issue | 1 | en_HK |
dc.identifier.spage | 189 | en_HK |
dc.identifier.epage | 192 | en_HK |
dc.identifier.isi | WOS:000233846700026 | - |
dc.publisher.place | United Kingdom | en_HK |
dc.identifier.scopusauthorid | Tang, OS=7006723402 | en_HK |
dc.identifier.scopusauthorid | Ong, CYT=7401968192 | en_HK |
dc.identifier.scopusauthorid | Tse, KY=8876026900 | en_HK |
dc.identifier.scopusauthorid | Ng, EHY=35238184300 | en_HK |
dc.identifier.scopusauthorid | Lee, SWH=26030998000 | en_HK |
dc.identifier.scopusauthorid | Ho, PC=7402211440 | en_HK |
dc.identifier.issnl | 0268-1161 | - |