HKU Scholars Hub: Project

Investigation of effects and molecular mechanisms of FGFR2-positive cancer-associate fibroblasts on tumor microenvironment in esophageal squamous cell carcinoma

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Grant Data

Project Title

Investigation of effects and molecular mechanisms of FGFR2-positive cancer-associate fibroblasts on tumor microenvironment in esophageal squamous cell carcinoma

Principal Investigator

Professor Guan, Xin-Yuan (Project Coordinator (PC))

Co-Investigator(s)

Professor Chen Zhiwei (Co-principal investigator)

Professor Ma Stephanie Kwai Yee (Co-principal investigator)

Dr Fu Grace Li (Co-principal investigator)

Duration

Start Date

2015-04-01

Amount

3487091

Conference Title

Investigation of effects and molecular mechanisms of FGFR2-positive cancer-associate fibroblasts on tumor microenvironment in esophageal squamous cell carcinoma

Presentation Title

Keywords

cancer microenvironment, cancer-associated fibroblast, esophageal cancer, FGFR2, immune surveillance

Discipline

Cancer,Cell Biology

HKU Project Code

C7038-14G

Grant Type

Collaborative Research Fund (CRF) - Group Research Project

Funding Year

2014

Status

Completed

Objectives

1) To characterize FGFR2+ cancer-associated fibroblasts (CAFs) in ESCC; 2) To investigate the effect of FGFR2+ CAFs on ESCC stemness; 3) To study the role of d42PD1/TLR4 pathway in modulating host immune surveillance.

All Publications

Title	Author(s)	Issue Date
TSPAN15 interacts with BTRC to promote oesophageal squamous cell carcinoma metastasis via activating NF-κB signaling Journal:Nature Communications	Zhang, B Zhang, Z Li, L Qin, Y Liu, H JIANG, C Zeng, T Li, M Xie, D Li, Y Guan, X Zhu, Y	2018
RNA editing of SLC22A3 drives early tumor invasion and metastasis in familial esophageal cancer Journal:Proceedings of the National Academy of Sciences	Fu, L Qin, YR Ming, X Zuo, XB Diao, YW Zhang, L Ai, J Liu, BL Huang, TX Cao, T Tan, BB Xiang, D Zeng, CM Gong, J Zhang, Q Dong, S Chen, J Liu, H Wu, JL Qi, RZ Xie, D Wang, LD Guan, X	2017
RHCG suppresses tumorigenicity and metastasis in esophageal squamous cell carcinoma via inhibiting NF-κB signaling and MMP1 expression Journal:Theranostics	Ming, X Zhang, X Cao, T Zhang, L Qi, J Kam, NW Tang, X Cui, Y Zhang, B Li, Y Qin, Y Guan, X	2018
Neuropilin-2 promotes tumourigenicity and metastasis in oesophageal squamous cell carcinoma through ERK-MAPK-ETV4-MMP-E-cadherin deregulation Journal:Journal of Pathology	Fung, TM Ng, KY Tong, M Chen, J Chai, S Chan, KT Law, S Lee, NP Choi, MY Li, B Cheung, AL Tsao, SW Qin, YR Guan, X Chan, KW Ma, S	2016
Monoclonal antibodies specific to human Δ42PD1: A novel immunoregulator potentially involved in HIV-1 and tumor pathogenesis Journal:MAbs	Cheng, L Tang, X Liu, L PENG, J Nishiura, K Cheung, KLA GUO, J WU, X Tang, H An, M ZHOU, J Cheung, KW Wang, H Guan, X Wu, Z Chen, Z	2015
Integrin α7 is a functional cancer stem cell surface marker in oesophageal squamous cell carcinoma Journal:Nature Communications	Ming, X Fu, L Zhang, L Qin, Y Cao, T Chan, KW Ma, SKY Xie, D Guan, X	2016
FSTL1 promotes metastasis and chemoresistance in esophageal squamous cell carcinoma through NFκB-BMP signaling cross-talk Journal:Cancer Research	Lau, MCC Ng, KY Wong, TL Tong, M Lee, TK Ming, X Law, S Lee, NP Cheung, AL Qin, YR Chan, KW Ning, W Guan, X Ma, S	2017
Expansion of cancer stem cell pool initiates lung cancer recurrence before angiogenesis Journal:Proceedings of the National Academy of Sciences	Li, L Li, J Yang, H Zhang, X Liu, L Li, Y Zeng, T Zhu, YH Li, XD Li, Y Xie, D Fu, L Guan, X	2018
CHD1L promotes lineage reversion of hepatocellular carcinoma through opening chromatin for key developmental transcription factors Journal:Hepatology	Liu, M Chow, KKR Li, Y Guan, X	2016