Investigation of effects and molecular mechanisms of FGFR2-positive cancer-associate fibroblasts on tumor microenvironment in esophageal squamous cell carcinoma
Grant Data
Project Title
Investigation of effects and molecular mechanisms of FGFR2-positive cancer-associate fibroblasts on tumor microenvironment in esophageal squamous cell carcinoma
Principal Investigator
Professor Guan, Xin-Yuan
(Project Coordinator (PC))
Co-Investigator(s)
Professor Chen Zhiwei
(Co-principal investigator)
Professor Ma Stephanie Kwai Yee
(Co-principal investigator)
Dr Fu Grace Li
(Co-principal investigator)
Duration
36
Start Date
2015-04-01
Amount
3487091
Conference Title
Investigation of effects and molecular mechanisms of FGFR2-positive cancer-associate fibroblasts on tumor microenvironment in esophageal squamous cell carcinoma
Presentation Title
Keywords
cancer microenvironment, cancer-associated fibroblast, esophageal cancer, FGFR2, immune surveillance
Discipline
Cancer,Cell Biology
HKU Project Code
C7038-14G
Grant Type
Collaborative Research Fund (CRF) - Group Research Project
Funding Year
2014
Status
Completed
Objectives
1) To characterize FGFR2+ cancer-associated fibroblasts (CAFs) in ESCC; 2) To investigate the effect of FGFR2+ CAFs on ESCC stemness; 3) To study the role of d42PD1/TLR4 pathway in modulating host immune surveillance.