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Conference Paper: Timeless interacts with Parp1 to promote homologous recombination repair

TitleTimeless interacts with Parp1 to promote homologous recombination repair
Authors
Xie, SMortusewicz, OMa, KPoon, RHelleday, TQian, C
Issue Date2014
Citation
The 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Hong Kong, 14 June 2014 How to Cite?
AbstractBoth Parp1 and Timeless have been implicated in DNA damage response, while there is no report that Parp1 could function together with Timeless. We have, for the first time, provided the evidence that Parp1 binds to Timeless both in vitro and in vivo. In addition, we present the crystal structure of Timeless in complex with Parp1, and demonstrate that Timeless-Parp1 complex facilitates homologous recombination repair.
DescriptionPoster presentation - Theme 1: Cell biology - Poster no. 24
Persistent Identifierhttp://hdl.handle.net/10722/203758

 

DC FieldValueLanguage
dc.contributor.authorXie, Sen_US
dc.contributor.authorMortusewicz, Oen_US
dc.contributor.authorMa, Ken_US
dc.contributor.authorPoon, Ren_US
dc.contributor.authorHelleday, Ten_US
dc.contributor.authorQian, Cen_US
dc.date.accessioned2014-09-19T16:40:56Z-
dc.date.available2014-09-19T16:40:56Z-
dc.date.issued2014en_US
dc.identifier.citationThe 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Hong Kong, 14 June 2014en_US
dc.identifier.urihttp://hdl.handle.net/10722/203758-
dc.descriptionPoster presentation - Theme 1: Cell biology - Poster no. 24-
dc.description.abstractBoth Parp1 and Timeless have been implicated in DNA damage response, while there is no report that Parp1 could function together with Timeless. We have, for the first time, provided the evidence that Parp1 binds to Timeless both in vitro and in vivo. In addition, we present the crystal structure of Timeless in complex with Parp1, and demonstrate that Timeless-Parp1 complex facilitates homologous recombination repair.en_US
dc.languageengen_US
dc.relation.ispartofHong Kong Inter-University Biochemistry Postgraduate Symposiumen_US
dc.titleTimeless interacts with Parp1 to promote homologous recombination repairen_US
dc.typeConference_Paperen_US
dc.identifier.emailQian, C: cmqian@hku.hken_US
dc.identifier.authorityQian, C=rp01371en_US
dc.identifier.hkuros237294en_US
dc.identifier.hkuros270512-

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