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Conference Paper: Low frequency optogenetic stimulation of dentate gyrus enhances brain functional connectivity revealed by resting-state fMRI

TitleLow frequency optogenetic stimulation of dentate gyrus enhances brain functional connectivity revealed by resting-state fMRI
Authors
Chan, RWLeung, ATLGao, PPChan, YSYung, WHTsia, KKMWu, EX
Issue Date2016
Citation
The 24th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2016), Singapore, 7-13 May 2016. How to Cite?
AbstractLow frequency coherent rsfMRI signals (<0.1Hz) do not match the bandwidth of established neuronal oscillations, highlighting a gap in our knowledge regarding the neuronal basis of rsfMRI underlying long-range brain networks. In this study, optogenetics and rsfMRI were combined to investigate the neuronal basis of rsfMRI connectivity by probing alternations of brain functional connectivity before, during and after low frequency stimulation in dorsal dentate gyrus. Our results demonstrated that low frequency optogenetic stimulation enhanced brain functional connectivity. This indicated that low frequency neuronal oscillations contribute and underlie the synchronized long-range rsfMRI brain functional networks.
DescriptionScientific Session - fMRI: The Cutting Edge in Connectivity: no. 0311
Chan, RW: 24th Annual Meeting of ISMRM Summa Cum Laude Merit Award Recipient
Persistent Identifierhttp://hdl.handle.net/10722/234964

 

DC FieldValueLanguage
dc.contributor.authorChan, RW-
dc.contributor.authorLeung, ATL-
dc.contributor.authorGao, PP-
dc.contributor.authorChan, YS-
dc.contributor.authorYung, WH-
dc.contributor.authorTsia, KKM-
dc.contributor.authorWu, EX-
dc.date.accessioned2016-10-14T13:50:24Z-
dc.date.available2016-10-14T13:50:24Z-
dc.date.issued2016-
dc.identifier.citationThe 24th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2016), Singapore, 7-13 May 2016.-
dc.identifier.urihttp://hdl.handle.net/10722/234964-
dc.descriptionScientific Session - fMRI: The Cutting Edge in Connectivity: no. 0311-
dc.descriptionChan, RW: 24th Annual Meeting of ISMRM Summa Cum Laude Merit Award Recipient-
dc.description.abstractLow frequency coherent rsfMRI signals (<0.1Hz) do not match the bandwidth of established neuronal oscillations, highlighting a gap in our knowledge regarding the neuronal basis of rsfMRI underlying long-range brain networks. In this study, optogenetics and rsfMRI were combined to investigate the neuronal basis of rsfMRI connectivity by probing alternations of brain functional connectivity before, during and after low frequency stimulation in dorsal dentate gyrus. Our results demonstrated that low frequency optogenetic stimulation enhanced brain functional connectivity. This indicated that low frequency neuronal oscillations contribute and underlie the synchronized long-range rsfMRI brain functional networks.-
dc.languageeng-
dc.relation.ispartofISMRM 2016 Annual Meeting & Exhibition-
dc.titleLow frequency optogenetic stimulation of dentate gyrus enhances brain functional connectivity revealed by resting-state fMRI-
dc.typeConference_Paper-
dc.identifier.emailChan, YS: yschan@hku.hk-
dc.identifier.emailTsia, KKM: tsia@hku.hk-
dc.identifier.emailWu, EX: ewu@eee.hku.hk-
dc.identifier.authorityChan, YS=rp00318-
dc.identifier.authorityTsia, KKM=rp01389-
dc.identifier.authorityWu, EX=rp00193-
dc.identifier.hkuros268302-

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