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Article: A Review of the Common Models Used in Mechanistic Studies on Demineralization-Remineralization for Cariology Research

TitleA Review of the Common Models Used in Mechanistic Studies on Demineralization-Remineralization for Cariology Research
Authors
KeywordsDemineralization
Remineralization
Fluoride
Caries
Review
Issue Date2017
PublisherMDPI AG. The Journal's web site is located at http://www.mdpi.com/journal/dentistry
Citation
Dentistry Journal, 2017, v. 5 n. 2, article no. 20 How to Cite?
AbstractMechanistic studies on demineralization-remineralization play a critical role in investigating caries pathogenicity, testing effects of new caries prevention methods, and developing new caries-preventing products. Simulating the cariogenic challenges in the mouth, various demineralization-remineralization models have been used for cariology research. This review aimed to provide an overview of the common mechanistic studies on demineralization-remineralization for cariology research in recent literature. Most mechanistic studies were in vitro studies (n = 294, 84%) among the 350 cariology studies indexed in the Web of Science from 2014 to 2016. Among these in vitro studies, most studies (257/294, 87%) used chemical models that could be classified as simple mineralization models (159/257, 62%) or pH-cycling models (98/257, 38%). In vitro studies consumed less expense and time than in vivo studies. Furthermore, in vitro conditions were easier to control. However, they could hardly imitate the complex structures of oral cavities, the microbiological effect of oral biofilm, and the hydrodynamic instability of saliva. The advantages of chemical models included simplicity of the study, low cost, efficiency (time saving), reproducibility, and stability of experiments. However, the “caries” generated were not biological. Moreover, the chemical models were generally basic and could not mimic a carious lesion in the complex oral environment.
Persistent Identifierhttp://hdl.handle.net/10722/242171
ISSN
2023 Impact Factor: 2.5
2023 SCImago Journal Rankings: 0.553
PubMed Central ID

 

DC FieldValueLanguage
dc.contributor.authorYu, OY-
dc.contributor.authorZhao, IS-
dc.contributor.authorMei, ML-
dc.contributor.authorLo, ECM-
dc.contributor.authorChu, CH-
dc.date.accessioned2017-07-24T01:36:18Z-
dc.date.available2017-07-24T01:36:18Z-
dc.date.issued2017-
dc.identifier.citationDentistry Journal, 2017, v. 5 n. 2, article no. 20-
dc.identifier.issn2304-6767-
dc.identifier.urihttp://hdl.handle.net/10722/242171-
dc.description.abstractMechanistic studies on demineralization-remineralization play a critical role in investigating caries pathogenicity, testing effects of new caries prevention methods, and developing new caries-preventing products. Simulating the cariogenic challenges in the mouth, various demineralization-remineralization models have been used for cariology research. This review aimed to provide an overview of the common mechanistic studies on demineralization-remineralization for cariology research in recent literature. Most mechanistic studies were in vitro studies (n = 294, 84%) among the 350 cariology studies indexed in the Web of Science from 2014 to 2016. Among these in vitro studies, most studies (257/294, 87%) used chemical models that could be classified as simple mineralization models (159/257, 62%) or pH-cycling models (98/257, 38%). In vitro studies consumed less expense and time than in vivo studies. Furthermore, in vitro conditions were easier to control. However, they could hardly imitate the complex structures of oral cavities, the microbiological effect of oral biofilm, and the hydrodynamic instability of saliva. The advantages of chemical models included simplicity of the study, low cost, efficiency (time saving), reproducibility, and stability of experiments. However, the “caries” generated were not biological. Moreover, the chemical models were generally basic and could not mimic a carious lesion in the complex oral environment.-
dc.languageeng-
dc.publisherMDPI AG. The Journal's web site is located at http://www.mdpi.com/journal/dentistry-
dc.relation.ispartofDentistry Journal-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectDemineralization-
dc.subjectRemineralization-
dc.subjectFluoride-
dc.subjectCaries-
dc.subjectReview-
dc.titleA Review of the Common Models Used in Mechanistic Studies on Demineralization-Remineralization for Cariology Research-
dc.typeArticle-
dc.identifier.emailYu, OY: ollieyu@hku.hk-
dc.identifier.emailMei, ML: mei1123@hku.hk-
dc.identifier.emailLo, ECM: edward-lo@hku.hk-
dc.identifier.emailChu, CH: chchu@hku.hk-
dc.identifier.authorityYu, OY=rp02658-
dc.identifier.authorityMei, ML=rp01840-
dc.identifier.authorityLo, ECM=rp00015-
dc.identifier.authorityChu, CH=rp00022-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.3390/dj5020020-
dc.identifier.pmid29563426-
dc.identifier.pmcidPMC5806972-
dc.identifier.scopuseid_2-s2.0-85032469448-
dc.identifier.hkuros273069-
dc.identifier.volume5-
dc.identifier.issue2-
dc.identifier.spagearticle no. 20-
dc.identifier.epagearticle no. 20-
dc.publisher.placeSwitzerland-
dc.identifier.issnl2304-6767-

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