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Article: Using Genomics Feature Selection Method in Radiomics Pipeline Improves Prognostication Performance in Locally Advanced Esophageal Squamous Cell Carcinoma-A Pilot Study

TitleUsing Genomics Feature Selection Method in Radiomics Pipeline Improves Prognostication Performance in Locally Advanced Esophageal Squamous Cell Carcinoma-A Pilot Study
Authors
Keywordsesophageal squamous cell carcinoma
neoadjuvant chemoradiotherapy
prognosis
radiogenomic
Issue Date2021
PublisherMDPI AG. The Journal's web site is located at http://www.mdpi.com/journal/cancers/
Citation
Cancers, 2021, v. 13 n. 9, p. article no. 2145 How to Cite?
AbstractPURPOSE: To evaluate the prognostic value of baseline and restaging CT-based radiomics with features associated with gene expression in esophageal squamous cell carcinoma (ESCC) patients receiving neoadjuvant chemoradiation (nCRT) plus surgery. METHODS: We enrolled 106 ESCC patients receiving nCRT from two institutions. Gene expression profiles of 28 patients in the training set were used to detect differentially expressed (DE) genes between patients with and without relapse. Radiomic features that were correlated to DE genes were selected, followed by additional machine learning selection. A radiomic nomogram for disease-free survival (DFS) prediction incorporating the radiomic signature and prognostic clinical characteristics was established for DFS estimation and validated. RESULTS: The radiomic signature with DE genes feature selection achieved better performance for DFS prediction than without. The nomogram incorporating the radiomic signature and lymph nodal status significantly stratified patients into high and low-risk groups for DFS (p < 0.001). The areas under the curve (AUCs) for predicting 5-year DFS were 0.912 in the training set, 0.852 in the internal test set, 0.769 in the external test set. CONCLUSIONS: Genomics association was useful for radiomic feature selection. The established radiomic signature was prognostic for DFS. The radiomic nomogram could provide a valuable prediction for individualized long-term survival.
Persistent Identifierhttp://hdl.handle.net/10722/300877
ISSN
2023 Impact Factor: 4.5
2023 SCImago Journal Rankings: 1.391
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorXie, CY-
dc.contributor.authorHu, YH-
dc.contributor.authorHo, JWK-
dc.contributor.authorHan, LJ-
dc.contributor.authorYang, H-
dc.contributor.authorWen, J-
dc.contributor.authorLam, KO-
dc.contributor.authorWong, IYH-
dc.contributor.authorLaw, SYK-
dc.contributor.authorChiu, KWH-
dc.contributor.authorFu, JH-
dc.contributor.authorVardhanabhuti, V-
dc.date.accessioned2021-07-06T03:11:26Z-
dc.date.available2021-07-06T03:11:26Z-
dc.date.issued2021-
dc.identifier.citationCancers, 2021, v. 13 n. 9, p. article no. 2145-
dc.identifier.issn2072-6694-
dc.identifier.urihttp://hdl.handle.net/10722/300877-
dc.description.abstractPURPOSE: To evaluate the prognostic value of baseline and restaging CT-based radiomics with features associated with gene expression in esophageal squamous cell carcinoma (ESCC) patients receiving neoadjuvant chemoradiation (nCRT) plus surgery. METHODS: We enrolled 106 ESCC patients receiving nCRT from two institutions. Gene expression profiles of 28 patients in the training set were used to detect differentially expressed (DE) genes between patients with and without relapse. Radiomic features that were correlated to DE genes were selected, followed by additional machine learning selection. A radiomic nomogram for disease-free survival (DFS) prediction incorporating the radiomic signature and prognostic clinical characteristics was established for DFS estimation and validated. RESULTS: The radiomic signature with DE genes feature selection achieved better performance for DFS prediction than without. The nomogram incorporating the radiomic signature and lymph nodal status significantly stratified patients into high and low-risk groups for DFS (p < 0.001). The areas under the curve (AUCs) for predicting 5-year DFS were 0.912 in the training set, 0.852 in the internal test set, 0.769 in the external test set. CONCLUSIONS: Genomics association was useful for radiomic feature selection. The established radiomic signature was prognostic for DFS. The radiomic nomogram could provide a valuable prediction for individualized long-term survival.-
dc.languageeng-
dc.publisherMDPI AG. The Journal's web site is located at http://www.mdpi.com/journal/cancers/-
dc.relation.ispartofCancers-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectesophageal squamous cell carcinoma-
dc.subjectneoadjuvant chemoradiotherapy-
dc.subjectprognosis-
dc.subjectradiogenomic-
dc.titleUsing Genomics Feature Selection Method in Radiomics Pipeline Improves Prognostication Performance in Locally Advanced Esophageal Squamous Cell Carcinoma-A Pilot Study-
dc.typeArticle-
dc.identifier.emailHo, JWK: jwkho@hku.hk-
dc.identifier.emailLam, KO: lamkaon@hku.hk-
dc.identifier.emailWong, IYH: iyhwong@hku.hk-
dc.identifier.emailLaw, SYK: slaw@hku.hk-
dc.identifier.emailChiu, KWH: kwhchiu@hku.hk-
dc.identifier.emailVardhanabhuti, V: varv@hku.hk-
dc.identifier.authorityHo, JWK=rp02436-
dc.identifier.authorityLam, KO=rp01501-
dc.identifier.authorityWong, IYH=rp02293-
dc.identifier.authorityLaw, SYK=rp00437-
dc.identifier.authorityChiu, KWH=rp02074-
dc.identifier.authorityVardhanabhuti, V=rp01900-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.3390/cancers13092145-
dc.identifier.pmid33946826-
dc.identifier.pmcidPMC8124289-
dc.identifier.scopuseid_2-s2.0-85107711362-
dc.identifier.hkuros323310-
dc.identifier.volume13-
dc.identifier.issue9-
dc.identifier.spagearticle no. 2145-
dc.identifier.epagearticle no. 2145-
dc.identifier.isiWOS:000649970800001-
dc.publisher.placeSwitzerland-
dc.identifier.issnl2072-6694-

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