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Article: Incidence and Demographics of Nasopharyngeal Carcinoma in Cheung Chau Island of Hong Kong—A Distinct Geographical Area With Minimal Residential Mobility and Restricted Public Healthcare Referral Network
Title | Incidence and Demographics of Nasopharyngeal Carcinoma in Cheung Chau Island of Hong Kong—A Distinct Geographical Area With Minimal Residential Mobility and Restricted Public Healthcare Referral Network |
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Authors | |
Keywords | nasopharyngeal carcinoma incidence mortality Cheung Chau Island Hong Kong |
Issue Date | 2021 |
Publisher | SAGE Publications, published in association with Moffitt Cancer Center. The Journal's web site is located at https://journals.sagepub.com/home/ccx |
Citation | Cancer Control, 2021, v. 28, p. article no. 107327482110471 How to Cite? |
Abstract | Background:
Nasopharyngeal carcinoma (NPC) is endemic in Hong Kong with a skewed geographical and ethnic distribution. We performed an epidemiological study of NPC in Cheung Chau Island, a fishing village with very minimal residential mobility, and compared its demographics and survival with the rest of Hong Kong.
Methods:
NPC data in Cheung Chau and non–Cheung Chau residents between 2006 and 2017 treated in our tertiary center were collected. The incidence, stage distribution, and mortality of Cheung Chau NPC residents were compared with those of their counterparts in the whole Hong Kong obtained from the Hong Kong Cancer Registry. Propensity score matching (PSM) was performed between Cheung Chau and non–Cheung Chau cases in a 1:4 ratio. Overall survival (OS), progression-free survival (PFS), and cancer-specific survival (CSS) were compared between these two cohorts by product limit estimation and log-rank tests.
Results:
Sixty-one patients residing in Cheung Chau were identified between 2006 and 2017. There was a significantly higher NPC incidence (P < .001) but an insignificant difference in the mortality rate in Cheung Chau compared to the whole Hong Kong data. After PSM with 237 non–Cheung Chau patients, the Cheung Chau cohort revealed a stronger NPC family history (P < .001). However, there were no significant differences in OS (P = .170), PFS (P = .053), and CSS (P = .160) between these two cohorts.
Conclusion:
Our results revealed that Cheung Chau had a higher NPC incidence but similar survival outcomes compared to the whole of Hong Kong. Further prospective studies are warranted to verify this finding and to explore the possible underlying mechanisms. |
Persistent Identifier | http://hdl.handle.net/10722/305309 |
ISSN | 2023 Impact Factor: 2.5 2023 SCImago Journal Rankings: 0.698 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | CHAN, SK | - |
dc.contributor.author | Chau, SC | - |
dc.contributor.author | Chan, SY | - |
dc.contributor.author | Tong, CC | - |
dc.contributor.author | Lam, KO | - |
dc.contributor.author | Kwong, DLW | - |
dc.contributor.author | Leung, TW | - |
dc.contributor.author | Luk, AY | - |
dc.contributor.author | Lee, AWM | - |
dc.contributor.author | Choi, HCW | - |
dc.contributor.author | Lee, VHF | - |
dc.date.accessioned | 2021-10-20T10:07:36Z | - |
dc.date.available | 2021-10-20T10:07:36Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | Cancer Control, 2021, v. 28, p. article no. 107327482110471 | - |
dc.identifier.issn | 1073-2748 | - |
dc.identifier.uri | http://hdl.handle.net/10722/305309 | - |
dc.description.abstract | Background: Nasopharyngeal carcinoma (NPC) is endemic in Hong Kong with a skewed geographical and ethnic distribution. We performed an epidemiological study of NPC in Cheung Chau Island, a fishing village with very minimal residential mobility, and compared its demographics and survival with the rest of Hong Kong. Methods: NPC data in Cheung Chau and non–Cheung Chau residents between 2006 and 2017 treated in our tertiary center were collected. The incidence, stage distribution, and mortality of Cheung Chau NPC residents were compared with those of their counterparts in the whole Hong Kong obtained from the Hong Kong Cancer Registry. Propensity score matching (PSM) was performed between Cheung Chau and non–Cheung Chau cases in a 1:4 ratio. Overall survival (OS), progression-free survival (PFS), and cancer-specific survival (CSS) were compared between these two cohorts by product limit estimation and log-rank tests. Results: Sixty-one patients residing in Cheung Chau were identified between 2006 and 2017. There was a significantly higher NPC incidence (P < .001) but an insignificant difference in the mortality rate in Cheung Chau compared to the whole Hong Kong data. After PSM with 237 non–Cheung Chau patients, the Cheung Chau cohort revealed a stronger NPC family history (P < .001). However, there were no significant differences in OS (P = .170), PFS (P = .053), and CSS (P = .160) between these two cohorts. Conclusion: Our results revealed that Cheung Chau had a higher NPC incidence but similar survival outcomes compared to the whole of Hong Kong. Further prospective studies are warranted to verify this finding and to explore the possible underlying mechanisms. | - |
dc.language | eng | - |
dc.publisher | SAGE Publications, published in association with Moffitt Cancer Center. The Journal's web site is located at https://journals.sagepub.com/home/ccx | - |
dc.relation.ispartof | Cancer Control | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | nasopharyngeal carcinoma | - |
dc.subject | incidence | - |
dc.subject | mortality | - |
dc.subject | Cheung Chau Island | - |
dc.subject | Hong Kong | - |
dc.title | Incidence and Demographics of Nasopharyngeal Carcinoma in Cheung Chau Island of Hong Kong—A Distinct Geographical Area With Minimal Residential Mobility and Restricted Public Healthcare Referral Network | - |
dc.type | Article | - |
dc.identifier.email | Lam, KO: lamkaon@hku.hk | - |
dc.identifier.email | Kwong, DLW: dlwkwong@hku.hk | - |
dc.identifier.email | Lee, AWM: awmlee@hkucc.hku.hk | - |
dc.identifier.email | Choi, HCW: hcchoi@hku.hk | - |
dc.identifier.email | Lee, VHF: vhflee@hku.hk | - |
dc.identifier.authority | Lam, KO=rp01501 | - |
dc.identifier.authority | Kwong, DLW=rp00414 | - |
dc.identifier.authority | Lee, AWM=rp02056 | - |
dc.identifier.authority | Choi, HCW=rp02815 | - |
dc.identifier.authority | Lee, VHF=rp00264 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1177/10732748211047117 | - |
dc.identifier.pmid | 34565216 | - |
dc.identifier.pmcid | PMC8642776 | - |
dc.identifier.scopus | eid_2-s2.0-85116004876 | - |
dc.identifier.hkuros | 327882 | - |
dc.identifier.volume | 28 | - |
dc.identifier.spage | article no. 107327482110471 | - |
dc.identifier.epage | article no. 107327482110471 | - |
dc.identifier.isi | WOS:000703098500001 | - |
dc.publisher.place | United Kingdom | - |