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Article: The effectiveness and safety of mRNA (BNT162b2) and inactivated (CoronaVac) COVID-19 vaccines among individuals with chronic kidney diseases

TitleThe effectiveness and safety of mRNA (BNT162b2) and inactivated (CoronaVac) COVID-19 vaccines among individuals with chronic kidney diseases
Authors
Issue Date2022
Citation
Kidney International, 2022 How to Cite?
AbstractThe ongoing coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has posed a serious threat to individuals with underlying chronic kidney disease (CKD). People with CKD are immunocompromised and therefore result in poorer outcomes including increased risk of hospitalization and mortality after COVID-19.1 Despite the availability of COVID-19 vaccines, current data on the vaccine efficacy in individuals with CKD are limited to surrogate endpoints such as antibody titers. As a result, a dedicated study is required to evaluate the effectiveness and safety of COVID-19 vaccines for the CKD population. In Hong Kong Special Administrative Region, China, a territory-wide vaccination program with BNT162b2 (Comirnaty; BioNTech/Pfizer/Fosun) and CoronaVac (CoronaVac Life Sciences) commenced on March 6, 2021, and February 23, 2021, respectively. BNT162b2 vaccine was the first SARS-CoV-2 mRNA vaccine approved by the US Food and Drug Administration,2 whereas CoronaVac is an inactivated whole-virion SARS-CoV-2 vaccine using adjuvant aluminum hydroxide.3 Using territory-wide electronic medical records and vaccination records, we conducted this population-based, retrospective study to evaluate the effectiveness and safety of COVID-19 vaccines in the CKD population.
Persistent Identifierhttp://hdl.handle.net/10722/316755
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorCheng, WTF-
dc.contributor.authorFAN, M-
dc.contributor.authorWong, CKH-
dc.contributor.authorChui, SLC-
dc.contributor.authorLai, TTF-
dc.contributor.authorLi, X-
dc.contributor.authorWan, YFE-
dc.contributor.authorTang, SCW-
dc.contributor.authorChan, EWY-
dc.contributor.authorWong, ICK-
dc.date.accessioned2022-09-16T07:22:49Z-
dc.date.available2022-09-16T07:22:49Z-
dc.date.issued2022-
dc.identifier.citationKidney International, 2022-
dc.identifier.urihttp://hdl.handle.net/10722/316755-
dc.description.abstractThe ongoing coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has posed a serious threat to individuals with underlying chronic kidney disease (CKD). People with CKD are immunocompromised and therefore result in poorer outcomes including increased risk of hospitalization and mortality after COVID-19.1 Despite the availability of COVID-19 vaccines, current data on the vaccine efficacy in individuals with CKD are limited to surrogate endpoints such as antibody titers. As a result, a dedicated study is required to evaluate the effectiveness and safety of COVID-19 vaccines for the CKD population. In Hong Kong Special Administrative Region, China, a territory-wide vaccination program with BNT162b2 (Comirnaty; BioNTech/Pfizer/Fosun) and CoronaVac (CoronaVac Life Sciences) commenced on March 6, 2021, and February 23, 2021, respectively. BNT162b2 vaccine was the first SARS-CoV-2 mRNA vaccine approved by the US Food and Drug Administration,2 whereas CoronaVac is an inactivated whole-virion SARS-CoV-2 vaccine using adjuvant aluminum hydroxide.3 Using territory-wide electronic medical records and vaccination records, we conducted this population-based, retrospective study to evaluate the effectiveness and safety of COVID-19 vaccines in the CKD population.-
dc.languageeng-
dc.relation.ispartofKidney International-
dc.titleThe effectiveness and safety of mRNA (BNT162b2) and inactivated (CoronaVac) COVID-19 vaccines among individuals with chronic kidney diseases-
dc.typeArticle-
dc.identifier.emailCheng, WTF: francowt@hku.hk-
dc.identifier.emailWong, CKH: carlosho@hku.hk-
dc.identifier.emailChui, SLC: cslchui@hku.hk-
dc.identifier.emailLai, TTF: fttlai@hku.hk-
dc.identifier.emailLi, X: sxueli@hku.hk-
dc.identifier.emailWan, YFE: yfwan@hku.hk-
dc.identifier.emailTang, SCW: scwtang@hku.hk-
dc.identifier.emailChan, EWY: ewchan@hku.hk-
dc.identifier.emailWong, ICK: wongick@hku.hk-
dc.identifier.authorityWong, CKH=rp01931-
dc.identifier.authorityChui, SLC=rp02527-
dc.identifier.authorityLai, TTF=rp02802-
dc.identifier.authorityLi, X=rp02531-
dc.identifier.authorityWan, YFE=rp02518-
dc.identifier.authorityTang, SCW=rp00480-
dc.identifier.authorityChan, EWY=rp01587-
dc.identifier.authorityWong, ICK=rp01480-
dc.identifier.doi10.1016/j.kint.2022.07.018-
dc.identifier.hkuros336392-
dc.identifier.isiWOS:000889512200010-

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