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Conference Paper: Change in volumes and radiation doses of parotid and submandibular glands during intensity modulated radiation therapy (IMRT) for nasopharyngeal carcinoma

TitleChange in volumes and radiation doses of parotid and submandibular glands during intensity modulated radiation therapy (IMRT) for nasopharyngeal carcinoma
Authors
Issue Date2011
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/ijrobp
Citation
The 53rd Annual Meeting of the American Society for Radiation Oncology (ASTRO 2011), Miami, FL., 2-6 October 2011. In International Journal of Radiation Oncology - Biology - Physics, 2011, v. 81 n. 2 suppl., p. S509-S510, abstract no. 2626 How to Cite?
AbstractPurpose/Objective(s): To investigate the changes in volumes and radiation doses to parotid and submandibular glands during IMRT for nasopharyngeal carcinoma in an attempt to justify re-planning in the mid-course of IMRT to minimize radiationinduced xerostomia. Materials/Methods: 33 consecutive patients with stage III to stage IVB nasopharyngeal carcinoma (AJCC Staging Manual 6th Edition) who received concurrent chemoradiation were included in this study. Computed tomography (CT) scans were performed for IMRT planning purposes (PLCT) and at mid-course of IMRT (MCCT) with head and neck immobilized by the same thermoplastic cast. Volumes of parotid and submandibular glands were outlined in these two set of CT images. Treatment plans were generated by planning systems for PLCT. PLCT of all patients were then co-registered with their corresponding MLCT. The treatment plans for PLCT were then copied to MCCT preserving the same beam shapes, angles and energies of PLCT. Dose distribution on MCCT was then re-calculated using this re-normalized plan so that differences in radiation dose will be due to anatomical and positioning changes rather than differences in dose calculation algorithms. Volumes of parotid and submandibular glands on PLCT and MCCT together with dosimetric parameters including D95, D50, D05, D01 and minimum, mean, maximum doses were compared by paired sample t-tests. Results: All 33 patients had their volumes of parotid and submandibular glands significantly reduced on MCCT (Table 1). The minimum and mean doses, D50, D05 and D01 of both parotids were significantly increased during mid-course while there was no difference of the dosimetric parameters of both submandibular glands before and during mid-course. Conclusions: The major salivary glands shrank and the parotids received a higher radiation dose during IMRT for nasopharyngeal carcinoma. This signifies that adaptive radiotherapy with re-planning should be seriously considered during course of IMRT as normal organs can receive an unexpected higher dose leading to more profound complications.
DescriptionPoster Viewing Session - PV-Head and Neck: abstract no. 2626
This journal suppl. entitled: Proceedings of the American Society for Radiation Oncology 53rd Annual Meeting
Persistent Identifierhttp://hdl.handle.net/10722/140581
ISSN
2017 Impact Factor: 5.554
2015 SCImago Journal Rankings: 2.274
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLee, Ven_US
dc.contributor.authorNg, SCYen_US
dc.contributor.authorKwong, DLWen_US
dc.contributor.authorHo, PPYen_US
dc.contributor.authorLeung, TWen_US
dc.contributor.authorAu, GKHen_US
dc.date.accessioned2011-09-23T06:15:19Z-
dc.date.available2011-09-23T06:15:19Z-
dc.date.issued2011en_US
dc.identifier.citationThe 53rd Annual Meeting of the American Society for Radiation Oncology (ASTRO 2011), Miami, FL., 2-6 October 2011. In International Journal of Radiation Oncology - Biology - Physics, 2011, v. 81 n. 2 suppl., p. S509-S510, abstract no. 2626en_US
dc.identifier.issn0360-3016-
dc.identifier.urihttp://hdl.handle.net/10722/140581-
dc.descriptionPoster Viewing Session - PV-Head and Neck: abstract no. 2626-
dc.descriptionThis journal suppl. entitled: Proceedings of the American Society for Radiation Oncology 53rd Annual Meeting-
dc.description.abstractPurpose/Objective(s): To investigate the changes in volumes and radiation doses to parotid and submandibular glands during IMRT for nasopharyngeal carcinoma in an attempt to justify re-planning in the mid-course of IMRT to minimize radiationinduced xerostomia. Materials/Methods: 33 consecutive patients with stage III to stage IVB nasopharyngeal carcinoma (AJCC Staging Manual 6th Edition) who received concurrent chemoradiation were included in this study. Computed tomography (CT) scans were performed for IMRT planning purposes (PLCT) and at mid-course of IMRT (MCCT) with head and neck immobilized by the same thermoplastic cast. Volumes of parotid and submandibular glands were outlined in these two set of CT images. Treatment plans were generated by planning systems for PLCT. PLCT of all patients were then co-registered with their corresponding MLCT. The treatment plans for PLCT were then copied to MCCT preserving the same beam shapes, angles and energies of PLCT. Dose distribution on MCCT was then re-calculated using this re-normalized plan so that differences in radiation dose will be due to anatomical and positioning changes rather than differences in dose calculation algorithms. Volumes of parotid and submandibular glands on PLCT and MCCT together with dosimetric parameters including D95, D50, D05, D01 and minimum, mean, maximum doses were compared by paired sample t-tests. Results: All 33 patients had their volumes of parotid and submandibular glands significantly reduced on MCCT (Table 1). The minimum and mean doses, D50, D05 and D01 of both parotids were significantly increased during mid-course while there was no difference of the dosimetric parameters of both submandibular glands before and during mid-course. Conclusions: The major salivary glands shrank and the parotids received a higher radiation dose during IMRT for nasopharyngeal carcinoma. This signifies that adaptive radiotherapy with re-planning should be seriously considered during course of IMRT as normal organs can receive an unexpected higher dose leading to more profound complications.-
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/ijrobp-
dc.relation.ispartofInternational Journal of Radiation Oncology - Biology - Physicsen_US
dc.titleChange in volumes and radiation doses of parotid and submandibular glands during intensity modulated radiation therapy (IMRT) for nasopharyngeal carcinomaen_US
dc.typeConference_Paperen_US
dc.identifier.emailLee, V: vhflee@hku.hken_US
dc.identifier.emailNg, SCY: ngchoryi@hku.hken_US
dc.identifier.emailKwong, DLW: dlwkwong@hkucc.hku.hken_US
dc.identifier.emailLeung, TW: ltw920@hkucc.hku.hk-
dc.identifier.emailAu, GKH: hkugkhau@hku.hk-
dc.identifier.authorityLee, V=rp00264en_US
dc.identifier.authorityKwong, DLW=rp00414en_US
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1016/j.ijrobp.2011.06.1041-
dc.identifier.hkuros194424en_US
dc.identifier.volume81-
dc.identifier.issue2 suppl.-
dc.identifier.spageS509, abstract no. 2626-
dc.identifier.epageS510, abstract no. 2626-
dc.identifier.isiWOS:000296411701126-
dc.publisher.placeUnited Kingdom-

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