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- Publisher Website: 10.1111/jog.13940
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- PMID: 30746853
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Article: Knowledge, Attitude And Ethical Consideration Of Chinese Couples Requesting Preimplantation Genetic Testing In Hong Kong
Title | Knowledge, Attitude And Ethical Consideration Of Chinese Couples Requesting Preimplantation Genetic Testing In Hong Kong |
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Authors | |
Keywords | Attitude Chinese couple Concern Preimplantation genetic testing |
Issue Date | 2019 |
Publisher | Wiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.wiley.com/WileyCDA/WileyTitle/productCd-JOG.html |
Citation | Journal of Obstetrics and Gynaecology Research, 2019, v. 45 n. 6, p. 1096-1105 How to Cite? |
Abstract | Aim: Increasing preimplantation genetic testing (PGT) cycles are being performed in Hong Kong. This study aims to evaluate the knowledge, attitude and ethical consideration of Chinese couples toward PGT.
Methods: Couples requesting PGT between June 2013 and March 2014 were invited to complete a questionnaire.
Results: Total 49 couples (49 women, 47 men) completed the questionnaires. Eighteen couples (37%) were waiting for PGT (pre‐PGT group), 15 couples (31%) were undergoing PGT (PGT group) and 16 couples (32%) had completed at least one PGT cycle (post‐PGT group). Only 53% of the couples could tell the recurrent risk, and 31% (with monogenic disorders) could tell the mode of inheritance of their condition. The acceptability of PGT (>80%) and attitude toward the embryo fate (58–78%) were good. The post‐PGT group had more concern than the PGT and pre‐PGT groups on the prenatal diagnostic testing (**P = 0.007). 12.5% of the couples worried about the transfer of healthy embryos with carrier state and they all had monogenic disorders. If the prenatal testing confirmed an affected fetus, a higher percentage (32%) in the Post‐PGT group disagreed to terminate the pregnancy in contrast to a much lower 6% in the pre‐PGT group (**P = 0.02). Three‐quarter of the couples opted to tell their child about their conception through PGT.
Conclusion: Chinese couples in Hong Kong had an overall good acceptability and positive attitude toward PGT. We appreciate the difficulties the couples have gone through PGT. A checklist on what to cover pre‐during‐post‐PGT in the counseling process is needed. |
Persistent Identifier | http://hdl.handle.net/10722/276090 |
ISSN | 2023 Impact Factor: 1.6 2023 SCImago Journal Rankings: 0.576 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Chan, SHS | - |
dc.contributor.author | Li, RHW | - |
dc.contributor.author | Lee, VCY | - |
dc.contributor.author | Tang, MHY | - |
dc.contributor.author | Ng, EHY | - |
dc.date.accessioned | 2019-09-10T02:55:44Z | - |
dc.date.available | 2019-09-10T02:55:44Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Journal of Obstetrics and Gynaecology Research, 2019, v. 45 n. 6, p. 1096-1105 | - |
dc.identifier.issn | 1341-8076 | - |
dc.identifier.uri | http://hdl.handle.net/10722/276090 | - |
dc.description.abstract | Aim: Increasing preimplantation genetic testing (PGT) cycles are being performed in Hong Kong. This study aims to evaluate the knowledge, attitude and ethical consideration of Chinese couples toward PGT. Methods: Couples requesting PGT between June 2013 and March 2014 were invited to complete a questionnaire. Results: Total 49 couples (49 women, 47 men) completed the questionnaires. Eighteen couples (37%) were waiting for PGT (pre‐PGT group), 15 couples (31%) were undergoing PGT (PGT group) and 16 couples (32%) had completed at least one PGT cycle (post‐PGT group). Only 53% of the couples could tell the recurrent risk, and 31% (with monogenic disorders) could tell the mode of inheritance of their condition. The acceptability of PGT (>80%) and attitude toward the embryo fate (58–78%) were good. The post‐PGT group had more concern than the PGT and pre‐PGT groups on the prenatal diagnostic testing (**P = 0.007). 12.5% of the couples worried about the transfer of healthy embryos with carrier state and they all had monogenic disorders. If the prenatal testing confirmed an affected fetus, a higher percentage (32%) in the Post‐PGT group disagreed to terminate the pregnancy in contrast to a much lower 6% in the pre‐PGT group (**P = 0.02). Three‐quarter of the couples opted to tell their child about their conception through PGT. Conclusion: Chinese couples in Hong Kong had an overall good acceptability and positive attitude toward PGT. We appreciate the difficulties the couples have gone through PGT. A checklist on what to cover pre‐during‐post‐PGT in the counseling process is needed. | - |
dc.language | eng | - |
dc.publisher | Wiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.wiley.com/WileyCDA/WileyTitle/productCd-JOG.html | - |
dc.relation.ispartof | Journal of Obstetrics and Gynaecology Research | - |
dc.rights | This is the peer reviewed version of the following article: Journal of Obstetrics and Gynaecology Research, 2019, v. 45 n. 6, p. 1096-1105, which has been published in final form at https://doi.org/10.1111/jog.13940. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. | - |
dc.subject | Attitude | - |
dc.subject | Chinese couple | - |
dc.subject | Concern | - |
dc.subject | Preimplantation genetic testing | - |
dc.title | Knowledge, Attitude And Ethical Consideration Of Chinese Couples Requesting Preimplantation Genetic Testing In Hong Kong | - |
dc.type | Article | - |
dc.identifier.email | Chan, SHS: sophehs@hku.hk | - |
dc.identifier.email | Li, RHW: raymondli@hku.hk | - |
dc.identifier.email | Tang, MHY: mhytang@hkucc.hku.hk | - |
dc.identifier.email | Ng, EHY: nghye@hku.hk | - |
dc.identifier.authority | Chan, SHS=rp02210 | - |
dc.identifier.authority | Li, RHW=rp01649 | - |
dc.identifier.authority | Tang, MHY=rp01701 | - |
dc.identifier.authority | Ng, EHY=rp00426 | - |
dc.description.nature | postprint | - |
dc.identifier.doi | 10.1111/jog.13940 | - |
dc.identifier.pmid | 30746853 | - |
dc.identifier.scopus | eid_2-s2.0-85061444623 | - |
dc.identifier.hkuros | 305213 | - |
dc.identifier.volume | 45 | - |
dc.identifier.issue | 6 | - |
dc.identifier.spage | 1096 | - |
dc.identifier.epage | 1105 | - |
dc.identifier.isi | WOS:000470007000002 | - |
dc.publisher.place | Australia | - |
dc.identifier.issnl | 1341-8076 | - |