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Patent History
- ApplicationCN 20098143026 2009-12-11
- PublicationCN 102203254 2011-09-28
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published patent: Sirna compositions and methods for potently inhibiting viral infection
Title | Sirna compositions and methods for potently inhibiting viral infection |
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Priority Date | 2009-12-11 PCT/CN2009001422 2008-12-11 US 12/121614P |
Inventors | |
Issue Date | 2011 |
Citation | China Published Patent Application CN 102203254. Beijing, PRC: State Intellectual Property Office (SIPO) of the P.R.C., 2011 How to Cite? |
Abstract | No antiviral regimen has been consistently successful in treating H5N1 virus infection. We demonstrate that a group of highly effective siRNAs targeting different H5N1 viral genes shares a unique motif, GGAGU/ ACUCC. We further demonstrate that the effectiveness of siRNAs containing this motif is not sequence specific. The results suggested that the structure of the unique motif is critical in determining the potency of siRNA-mediated protective effects against viral infection and this potent in vivo protection is associated with early productions of ss-defensin and IL-6 induced by the motif. Provided are methods and prophylactic and therapeutic agents useful against other viral infections in addition to the H5N1 influenza virus. |
Persistent Identifier | http://hdl.handle.net/10722/176641 |
DC Field | Value | Language |
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dc.date.accessioned | 2012-11-30T08:38:17Z | - |
dc.date.available | 2012-11-30T08:38:17Z | - |
dc.date.issued | 2011 | - |
dc.identifier.citation | China Published Patent Application CN 102203254. Beijing, PRC: State Intellectual Property Office (SIPO) of the P.R.C., 2011 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/176641 | - |
dc.description.abstract | No antiviral regimen has been consistently successful in treating H5N1 virus infection. We demonstrate that a group of highly effective siRNAs targeting different H5N1 viral genes shares a unique motif, GGAGU/ ACUCC. We further demonstrate that the effectiveness of siRNAs containing this motif is not sequence specific. The results suggested that the structure of the unique motif is critical in determining the potency of siRNA-mediated protective effects against viral infection and this potent in vivo protection is associated with early productions of ss-defensin and IL-6 induced by the motif. Provided are methods and prophylactic and therapeutic agents useful against other viral infections in addition to the H5N1 influenza virus. | en_HK |
dc.title | Sirna compositions and methods for potently inhibiting viral infection | en_HK |
dc.type | Patent | en_US |
dc.description.nature | published_or_final_version | en_US |
dc.contributor.inventor | Zheng, B | en_HK |
dc.contributor.inventor | Sui Hongyan | en_HK |
dc.contributor.inventor | Lin Yongping | en_HK |
patents.identifier.application | CN 20098143026 | en_HK |
patents.description.assignee | UNIV HONG KONG | en_HK |
patents.description.country | China, PRC | en_HK |
patents.date.publication | 2011-09-28 | en_HK |
patents.date.application | 2009-12-11 | en_HK |
patents.date.priority | 2009-12-11 PCT/CN2009001422 | en_HK |
patents.date.priority | 2008-12-11 US 12/121614P | en_HK |
patents.description.cc | CN | en_HK |
patents.identifier.publication | CN 102203254 | en_HK |
patents.relation.family | CN 102203254 (A) 2011-09-28 | en_HK |
patents.relation.family | EP 2356236 (A1) 2011-08-17 | en_HK |
patents.relation.family | US 2010166661 (A1) 2010-07-01 | en_HK |
patents.relation.family | WO 2010066112 (A1) 2010-06-17 | en_HK |
patents.description.kind | A | en_HK |
patents.type | Patent_published | en_HK |