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Patent History
- ApplicationUS 12/636234 2009-12-11
- PublicationUS 2010166661 2010-07-01
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published patent: siRNA COMPOSITIONS AND METHODS FOR POTENTLY INHIBITING VIRAL INFECTION
Title | siRNA COMPOSITIONS AND METHODS FOR POTENTLY INHIBITING VIRAL INFECTION |
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Priority Date | 2009-12-11 US 12/636234 2008-12-11 US 12/121614P |
Inventors | |
Issue Date | 2010 |
Citation | US Published patent application US 2010166661. Washington, DC: US Patent and Trademark Office (USPTO), 2010 How to Cite? |
Abstract | No antiviral regimen has been consistently successful in treating H5N1 virus infection. We demonstrate that a group of highly effective siRNAs targeting different H5N1 viral genes shares a unique motif, GGAGU/ACUCC. We further demonstrate that the effectiveness of siRNAs containing this motif is not sequence specific. The results suggested that the structure of the unique motif is critical in determining the potency of siRNA-mediated protective effects against viral infection and this potent in vivo protection is associated with early productions of [beta]-defensin and IL-6 induced by the motif. Provided are methods and prophylactic and therapeutic agents useful against other viral infections in addition to the H5N1 influenza virus. |
Persistent Identifier | http://hdl.handle.net/10722/176998 |
References |
DC Field | Value | Language |
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dc.date.accessioned | 2012-11-30T08:38:55Z | - |
dc.date.available | 2012-11-30T08:38:55Z | - |
dc.date.issued | 2010 | - |
dc.identifier.citation | US Published patent application US 2010166661. Washington, DC: US Patent and Trademark Office (USPTO), 2010 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/176998 | - |
dc.description.abstract | No antiviral regimen has been consistently successful in treating H5N1 virus infection. We demonstrate that a group of highly effective siRNAs targeting different H5N1 viral genes shares a unique motif, GGAGU/ACUCC. We further demonstrate that the effectiveness of siRNAs containing this motif is not sequence specific. The results suggested that the structure of the unique motif is critical in determining the potency of siRNA-mediated protective effects against viral infection and this potent in vivo protection is associated with early productions of [beta]-defensin and IL-6 induced by the motif. Provided are methods and prophylactic and therapeutic agents useful against other viral infections in addition to the H5N1 influenza virus. | en_HK |
dc.title | siRNA COMPOSITIONS AND METHODS FOR POTENTLY INHIBITING VIRAL INFECTION | en_HK |
dc.type | Patent | en_US |
dc.description.nature | published_or_final_version | en_US |
dc.contributor.inventor | Zheng, B | en_HK |
dc.contributor.inventor | Sui Hongyan | en_HK |
dc.contributor.inventor | Lin Yongping | en_HK |
patents.identifier.application | US 12/636234 | en_HK |
patents.description.country | United States of America | en_HK |
patents.date.publication | 2010-07-01 | en_HK |
dc.relation.references | US 2004242518 (A1) 2004-12-02 | - |
patents.identifier.hkutechid | Micro-2008-00295-1 | - |
patents.date.application | 2009-12-11 | en_HK |
patents.date.priority | 2009-12-11 US 12/636234 | en_HK |
patents.date.priority | 2008-12-11 US 12/121614P | en_HK |
patents.description.cc | US | en_HK |
patents.identifier.publication | US 2010166661 | en_HK |
patents.relation.family | CN 102203254 (A) 2011-09-28 | en_HK |
patents.relation.family | EP 2356236 (A1) 2011-08-17 | en_HK |
patents.relation.family | US 2010166661 (A1) 2010-07-01 | en_HK |
patents.relation.family | WO 2010066112 (A1) 2010-06-17 | en_HK |
patents.description.kind | A1 | en_HK |
patents.type | Patent_published | en_HK |