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Patent History
- ApplicationPC T/CN2009001422 2009-12-11
- PublicationWO 2010066112 2010-06-17
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published patent: siRNA COMPOSITIONS AND METHODS FOR POTENTLY INHIBITING VIRAL INFECTION
Title | siRNA COMPOSITIONS AND METHODS FOR POTENTLY INHIBITING VIRAL INFECTION |
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Priority Date | 2008-12-11 US 12/121614P |
Inventors | |
Issue Date | 2010 |
Citation | WO Published patent application WO 2010066112. World Intellectual Property Organization (WIPO), PatentScope, 2010 How to Cite? |
Abstract | No antiviral regimen has been consistently successful in treating H5N1 virus infection. We demonstrate that a group of highly effective siRNAs targeting different H5N1 viral genes shares a unique motif, GGAGU/ ACUCC. We further demonstrate that the effectiveness of siRNAs containing this motif is not sequence specific. The results suggested that the structure of the unique motif is critical in determining the potency of siRNA-mediated protective effects against viral infection and this potent in vivo protection is associated with early productions of ss-defensin and IL-6 induced by the motif. Provided are methods and prophylactic and therapeutic agents useful against other viral infections in addition to the H5N1 influenza virus. |
Persistent Identifier | http://hdl.handle.net/10722/177144 |
DC Field | Value | Language |
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dc.date.accessioned | 2012-11-30T08:39:13Z | - |
dc.date.available | 2012-11-30T08:39:13Z | - |
dc.date.issued | 2010 | - |
dc.identifier.citation | WO Published patent application WO 2010066112. World Intellectual Property Organization (WIPO), PatentScope, 2010 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/177144 | - |
dc.description.abstract | No antiviral regimen has been consistently successful in treating H5N1 virus infection. We demonstrate that a group of highly effective siRNAs targeting different H5N1 viral genes shares a unique motif, GGAGU/ ACUCC. We further demonstrate that the effectiveness of siRNAs containing this motif is not sequence specific. The results suggested that the structure of the unique motif is critical in determining the potency of siRNA-mediated protective effects against viral infection and this potent in vivo protection is associated with early productions of ss-defensin and IL-6 induced by the motif. Provided are methods and prophylactic and therapeutic agents useful against other viral infections in addition to the H5N1 influenza virus. | en_HK |
dc.title | siRNA COMPOSITIONS AND METHODS FOR POTENTLY INHIBITING VIRAL INFECTION | en_HK |
dc.type | Patent | en_US |
dc.description.nature | published_or_final_version | en_US |
dc.contributor.inventor | Zheng, B | en_HK |
dc.contributor.inventor | Sui, Hongyan | en_HK |
dc.contributor.inventor | Lin, Yongping | en_HK |
patents.identifier.application | PC T/CN2009001422 | en_HK |
patents.description.assignee | UNIV HONG KONG [CN]; ZHENG BOJIAN [CN]; SUI HONGYAN [US]; LIN YONGPING [CN] | en_HK |
patents.description.country | World Intellectual Property Organization (WIPO) | en_HK |
patents.date.publication | 2010-06-17 | en_HK |
patents.date.application | 2009-12-11 | en_HK |
patents.date.priority | 2008-12-11 US 12/121614P | en_HK |
patents.description.cc | WO | en_HK |
patents.identifier.publication | WO 2010066112 | en_HK |
patents.relation.family | CN 102203254 (A) 2011-09-28 | en_HK |
patents.relation.family | EP 2356236 (A1) 2011-08-17 | en_HK |
patents.relation.family | US 2010166661 (A1) 2010-07-01 | en_HK |
patents.relation.family | WO 2010066112 (A1) 2010-06-17 | en_HK |
patents.description.kind | A1 | en_HK |
patents.type | Patent_published | en_HK |