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Conference Paper: NFE2L2 mutations are predictive and prognostic of treatment outcome in resectable esophageal squmaous cell carcinoma patients (Poster Presentation)

TitleNFE2L2 mutations are predictive and prognostic of treatment outcome in resectable esophageal squmaous cell carcinoma patients (Poster Presentation)
Authors
Issue Date30-Aug-2023
PublisherOxford University Press
Abstract

Background

The poor prognosis of resectable esophageal squamous cell carcinoma (ESCC) poses an unmet need to identify genomic early predictive and prognostic biomarkers to improve treatment outcome and risk stratification.

Methods

Retrospective targeted sequencing was performed on 80 ESCC formalin-fixed, paraffin-embedded (FFPE) tumor specimens from 37 good responders and 43 poor responders receiving neoadjuvant treatment. Somatic mutations and copy number variations (CNVs) were detected in 130 cancer druggable genes with TOMA Os-seq. Kaplan Meier curve and COX regression analysis were used to estimate the risk of relapse and survival.

Results

Twelve patients (12/80, 15%) with hot spot NFE2L2 mutations occurred with significantly higher frequency in poor responders (p = 0.0003) and in patients with non-complete pathological response (p = 0.007) in resectable ESCC treated by chemo-radiotherapy (CRT). These patients also had poorer prognosis with higher risk of death (HR = 1.942, p = 0.039) and relapse (HR = 1.817, p = 0.063) by COX analysis. The independent prognostic role of hot spot NFE2L2 mutations was validated by the presence of recurrent plasma cell-free (ct)-DNA NFE2L2 mutations in an independent prospective cohort of resectable ESCC patients.

Conclusions

In summary, our study now demonstrates the clinical usefulness of hot spot NFE2L2 mutations, as a potential predictive and prognostic biomarker associated with pre-surgery CRT responses, and provides novel insights for future therapeutic options targeting the NRF signaling in resectable ESCC treated by neoadjuvant CRT. The novel prognostic role of hot spot NFE2L2 mutations may be useful markers to guide clinicians for treatment decisions in resectable ESCC patients following pre-surgery treatment.


Persistent Identifierhttp://hdl.handle.net/10722/340510
ISSN
2023 Impact Factor: 2.3
2023 SCImago Journal Rankings: 1.038

 

DC FieldValueLanguage
dc.contributor.authorKo, JMY-
dc.contributor.authorChen, G-
dc.contributor.authorLo, AWI-
dc.contributor.authorTao, L-
dc.contributor.authorLaw, SYK-
dc.contributor.authorLam, KO-
dc.contributor.authorKwong, DLW-
dc.contributor.authorWong, IYH-
dc.contributor.authorWong, CLY-
dc.contributor.authorChan, SY-
dc.contributor.authorChan, KK-
dc.contributor.authorLaw, TT-
dc.contributor.authorLeung, AKK-
dc.contributor.authorWong, CWY-
dc.contributor.authorDai, W-
dc.contributor.authorLung, ML-
dc.date.accessioned2024-03-11T10:45:10Z-
dc.date.available2024-03-11T10:45:10Z-
dc.date.issued2023-08-30-
dc.identifier.issn1120-8694-
dc.identifier.urihttp://hdl.handle.net/10722/340510-
dc.description.abstract<p>Background</p><p>The poor prognosis of resectable esophageal squamous cell carcinoma (ESCC) poses an unmet need to identify genomic early predictive and prognostic biomarkers to improve treatment outcome and risk stratification.</p><p>Methods</p><p>Retrospective targeted sequencing was performed on 80 ESCC formalin-fixed, paraffin-embedded (FFPE) tumor specimens from 37 good responders and 43 poor responders receiving neoadjuvant treatment. Somatic mutations and copy number variations (CNVs) were detected in 130 cancer druggable genes with TOMA Os-seq. Kaplan Meier curve and COX regression analysis were used to estimate the risk of relapse and survival.</p><p>Results</p><p>Twelve patients (12/80, 15%) with hot spot NFE2L2 mutations occurred with significantly higher frequency in poor responders (p = 0.0003) and in patients with non-complete pathological response (p = 0.007) in resectable ESCC treated by chemo-radiotherapy (CRT). These patients also had poorer prognosis with higher risk of death (HR = 1.942, p = 0.039) and relapse (HR = 1.817, p = 0.063) by COX analysis. The independent prognostic role of hot spot NFE2L2 mutations was validated by the presence of recurrent plasma cell-free (ct)-DNA NFE2L2 mutations in an independent prospective cohort of resectable ESCC patients.</p><p>Conclusions</p><p>In summary, our study now demonstrates the clinical usefulness of hot spot NFE2L2 mutations, as a potential predictive and prognostic biomarker associated with pre-surgery CRT responses, and provides novel insights for future therapeutic options targeting the NRF signaling in resectable ESCC treated by neoadjuvant CRT. The novel prognostic role of hot spot NFE2L2 mutations may be useful markers to guide clinicians for treatment decisions in resectable ESCC patients following pre-surgery treatment.</p>-
dc.languageeng-
dc.publisherOxford University Press-
dc.relation.ispartofDiseases of the Esophagus-
dc.titleNFE2L2 mutations are predictive and prognostic of treatment outcome in resectable esophageal squmaous cell carcinoma patients (Poster Presentation)-
dc.typeConference_Paper-
dc.identifier.doi10.1093/dote/doad052.168-
dc.identifier.volume36-
dc.identifier.issueSupplement 2-
dc.identifier.spage59-
dc.identifier.epage59-
dc.identifier.eissn1442-2050-
dc.identifier.issnl1120-8694-

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